Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/9026
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dc.contributor.authorOzkan, Didem-
dc.contributor.authorAkisin, Yasemin Ardicoglu-
dc.contributor.authorBali, Dilara Fatma Akin-
dc.contributor.authorAkar, Nejat-
dc.date.accessioned2022-11-30T19:26:30Z-
dc.date.available2022-11-30T19:26:30Z-
dc.date.issued2022-
dc.identifier.issn2667-663X-
dc.identifier.urihttps://doi.org/10.4328/ACAM.21174-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/9026-
dc.description.abstractAim: Macrothrombocytopenia is a congenital autosomal-dominant blood disorder characterized by increased platelet size and a decreased number of circulating platelets. In this study, it was aimed to show the MYH9 and TUBB1 gene changes, which are the genes associated with the disease, in a patient with thrombocytopenia receiving beta-lactam antibiotic therapy. Material and Methods: In this study, coagulation parameters and platelet aggregation tests were performed after ingestion of a beta-lactam antibiotic in an 8-year-old boy with thrombocytopenia, the MYH9 and TUBB1 genes were scanned by PCR and DNA sequencing, and the results were subsequently analyzed using bioinformatics tools. Results: We found previously described TUBB1 polymorphisms, p.R307H , p.Q43P, p.T178T and the novel mutation p.K64A in the MYH9 gene in a boy and his mother. Changes in genes important for thrombocytopenia in a boy after taking beta-lactam antibiotics prompted us to study the same genes in the mother, since her mother had macrothrombocytopenia, and we found a new mutation in her mother Discussion: Determination of gene changes after beta-lactam antibiotic use in bleeding patients is important in terms of helping the clinic in the treatment.en_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlateletsen_US
dc.subjectMacrothrombocytopeniaen_US
dc.subjectMYH9en_US
dc.subjectPlateleten_US
dc.subjectMacrothrombocytopeniaen_US
dc.titleBeta-lactam antibiotic-induced thrombocytopenia: MYH9 & TUBB1 genesen_US
dc.typeArticleen_US
dc.identifier.volume13en_US
dc.identifier.issue9en_US
dc.identifier.startpage973en_US
dc.identifier.endpage977en_US
dc.identifier.wosWOS:000863271700007en_US
dc.institutionauthorArdiçoglu Akisin, Nazife Yasemin-
dc.institutionauthorAkar, Nejat-
dc.identifier.doi10.4328/ACAM.21174-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.ozel2022v3_Editen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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