Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1018
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAltuntaş, Sevde-
dc.contributor.authorBüyükserin, Fatih-
dc.contributor.authorHaider, Ali-
dc.contributor.authorAltınok, Büket-
dc.contributor.authorBıyıkli, Necmi-
dc.contributor.authorAslim, Belma-
dc.date.accessioned2019-05-23T05:48:44Z
dc.date.available2019-05-23T05:48:44Z
dc.date.issued2016-10
dc.identifier.citationAltuntas, S., Buyukserin, F., Haider, A., Altinok, B., Biyikli, N., & Aslim, B. (2016). Protein-releasing conductive anodized alumina membranes for nerve-interface materials. Materials Science and Engineering: C, 67, 590-598.en_US
dc.identifier.issn0928-4931
dc.identifier.othernumber of pages 9
dc.identifier.urihttps://doi.org/10.1016/j.msec.2016.05.084-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/1018-
dc.description.abstractNanoporous anodized alumina membranes (AAMs) have numerous biomedical applications spanning from biosensors to controlled drug delivery and implant coatings. Although the use of AAM as an alternative bone implant surface has been successful, its potential as a neural implant coating remains unclear. Here, we introduce conductive and nerve growth factor-releasing AAM substrates that not only provide the native nanoporous morphology for cell adheSion, but also induce neural differentiation. We recently reported the fabrication of such conductive membranes by coating AAMs with a thin C layer. In this study, we investigated the influence of electrical stimulus, surface topography, and chemistry on cell adhesion, neurite extension, and density by using PC 12 pheochromocytoma cells in a custom-made glass microwell setup. The conductive AAMs showed enhanced neurite extension and generation with the electrical stimulus, but cell adhesion on these substrates was poorer compared to the naked AAMs. The latter nanoporous material presents chemical and topographical features for superior neuronal cell adhesion, but more importantly, when loaded with nerve growth factor, it can provide neurite extension similar to an electrically stimulated CAAM counterpart. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpc12 cellsen_US
dc.subjectelectrical stimulationen_US
dc.subjectalumina membranesen_US
dc.subjectnanotechnologyen_US
dc.subjectbiomaterialsen_US
dc.titleProtein-releasing conductive anodized alumina membranes for nerve-interface materialsen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume67
dc.identifier.startpage590
dc.identifier.endpage598
dc.relation.tubitakScientific and Technological Research Council of Turkey [111M686]en_US
dc.authorid0000-0001-6365-3808-
dc.identifier.wosWOS:000378952800067en_US
dc.identifier.scopus2-s2.0-84971320462en_US
dc.institutionauthorBüyükserin, Fatih-
dc.identifier.pmid27287158en_US
dc.identifier.doi10.1016/j.msec.2016.05.084-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

9
checked on Sep 23, 2022

WEB OF SCIENCETM
Citations

8
checked on Sep 24, 2022

Page view(s)

110
checked on Dec 5, 2022

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.