Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1022
Title: Controlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibers
Authors: Kabay, Gözde
Meydan, Ahmet Ersin
Kaleli Can, Gizem
Demirci, Ceylan
Mutlu, Mehmet
Keywords: drug release
amyloid-like bovine serum albumin
controlled release
blend electrospinning
ampicillin
Issue Date: Dec-2017
Publisher: Elsevier Science Bv
Source: Kabay, G., Meydan, A. E., Can, G. K., Demirci, C., & Mutlu, M. (2017). Controlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibers. Materials Science and Engineering: C, 81, 271-279.
Abstract: In this study, a controlled drug release platform, amyloid-like bovine serum albumin (AL-BSA) with ampicillin sodium salt (amp), was developed. To develop this platform, 5%, 10%, and 20% (w/w) ratios of amp:BSA were used with electrospinning to prepare nanofibers with average diameters of 132 +/- 69, 159 +/- 60, and 179 +/- 42 nm, respectively. Fourier transform infrared spectroscopy demonstrated that AL-BSA could entrap large amounts of drug inside the nanofibers, which was attributed to the antimicrobial activity of the released drug against Escherichia coli and Staphylococcus aureus. The amount of drug released was measured by UV-VIS spectrophotometry. The nanofibrous matrix of the electrospun membrane showed controlled release behavior in all samples. The transport mechanism was Fickian for the low ratio of amp:BSA (5% w:w). When the drug ratio was increased to > 10% (w:w), thicker fiber structures formed, suggesting that the drug traveled a longer distance to reach the fiber surface; thus, the mechanism of transport shifted from Fickian to non-Fickian.
URI: https://doi.org/10.1016/j.msec.2017.08.003
https://hdl.handle.net/20.500.11851/1022
ISSN: 0928-4931
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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