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Title: Controlled release of a hydrophilic drug from coaxially electrospun polycaprolactone nanofibers
Authors: Sultanova, Zahida
Kaleli, Gizem
Kabay, Gözde
Mutlu, Mehmet
Keywords: modified coaxial electrospinning
zero order drug release
controlled drug release
core-shell fibers
Issue Date: May-2016
Publisher: Elsevier Science Bv
Source: Sultanova, Z., Kaleli, G., Kabay, G., & Mutlu, M. (2016). Controlled release of a hydrophilic drug from coaxially electrospun polycaprolactone nanofibers. International journal of pharmaceutics, 505(1-2), 133-138.
Abstract: A recent approach for controlled release of drugs is the production of core-shell fibers via modified coaxial electrospinning where a shell solution which is not fully electrospinnable can be used. In this study, this technique was used for achieving the controlled release of a model hydrophilic drug (ampicillin) which is known to have a low compatibility with the polymer (polycaprolactone). A partially electrospinnable shell fluid (4% (w/v) polycaprolactone (PCL) solution) and a fully electrospinnable core fluid (10% (w/v) PCL, 2% (w/v) ampicillin solution) were used in order to create ampicillin-loaded PCL nanofibers covered by a PCL shield. Scanning electron microscopy and optical microscopy images proved that the membranes have core-shell structured nanofibers. Fourier transform infrared spectroscopy demonstrated that some compatibility might be present between ampicillin and PCL. Finally, drug release studies showed that the drug release kinetics of core-shell products is closer to zero-order kinetics while the drug release kinetics of single electrospinning of the core resulted with serious burst release. Together, these imply that the application area of modified coaxial electrospinning in controlled release could be expanded to polymers and drugs with low compatibility. (C) 2016 Elsevier B.V. All rights reserved.
ISSN: 0378-5173
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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