Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.11851/10328
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Palabıyık-Yücelik, Şaziye Sezin | - |
dc.contributor.author | Zeybek, Naciye Dilara | - |
dc.contributor.author | Çınar, İrfan | - |
dc.contributor.author | Akpınar, Erol | - |
dc.contributor.author | Zırh, Elham Bahador | - |
dc.contributor.author | Sipahi, Hande | - |
dc.contributor.author | Halıcı, Zekai | - |
dc.date.accessioned | 2023-04-16T10:00:18Z | - |
dc.date.available | 2023-04-16T10:00:18Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1382-6689 | - |
dc.identifier.issn | 1872-7077 | - |
dc.identifier.uri | https://doi.org/10.1016/j.etap.2023.104061 | - |
dc.identifier.uri | https://hdl.handle.net/20.500.11851/10328 | - |
dc.description.abstract | Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-Daspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a wellknown antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl3) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl3 pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were downregulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG treatment has shown a better neuroprotective effect in terms of these mechanisms and represents novel approach for the prevention of neurodegenerative diseases likely to be induced by Al. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkiye (TUBITAK) [115S533] | en_US |
dc.description.sponsorship | This study was supported by the The Scientific and Technological Research Council of Turkiye (TUBITAK) with the number of 115S533. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Environmental Toxicology and Pharmacology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Aluminum | en_US |
dc.subject | Neurotoxicity | en_US |
dc.subject | Epigallocatechin gallate | en_US |
dc.subject | NMDAR | en_US |
dc.subject | Nitric-Oxide | en_US |
dc.subject | Acetylcholinesterase Activity | en_US |
dc.subject | Inhibition | en_US |
dc.subject | Expression | en_US |
dc.subject | Diseases | en_US |
dc.subject | Stress | en_US |
dc.subject | Assay | en_US |
dc.subject | Acid | en_US |
dc.title | Effects of simultaneous versus post exposure epigallocatechin-3-gallate treatment on aluminum induced neurotoxicity in rat hippocampus: A multi-approach study | en_US |
dc.type | Article | en_US |
dc.department | TOBB ETÜ | en_US |
dc.identifier.volume | 98 | en_US |
dc.identifier.wos | WOS:000920582800001 | en_US |
dc.identifier.scopus | 2-s2.0-85145818894 | en_US |
dc.institutionauthor | … | - |
dc.identifier.pmid | 36621558 | en_US |
dc.identifier.doi | 10.1016/j.etap.2023.104061 | - |
dc.authorscopusid | 57218908359 | - |
dc.authorscopusid | 8540689700 | - |
dc.authorscopusid | 55355223200 | - |
dc.authorscopusid | 23392019500 | - |
dc.authorscopusid | 57221571018 | - |
dc.authorscopusid | 16317388100 | - |
dc.authorscopusid | 6508093438 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopusquality | Q1 | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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