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Title: How does hemodynamics affect rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters, time-averaged wall shear stress, oscillatory shear index, endothelial cell activation potential, and relative residence time
Authors: Mutlu, O.
Salman, H.E.
Al-Thani, H.
El-Menyar, A.
Qidwai, U.A.
Yalcin, H.C.
Keywords: Abdominal aortic aneurysm (AAA)
Aneurysm rupture risk assessment
Computational fluid dynamics (CFD)
Endothelial cell activation potential (ECAP)
Oscillatory shear index (OSI)
Relative residence time (RRT)
Time average wall shear stress (TAWSS)
Blood vessels
Chemical activation
Computational fluid dynamics
Health risks
Risk assessment
Shear stress
Abdominal aortic aneurysm
Abdominal aortic aneurysms
Activation potential
Aneurysm rupture
Aneurysm rupture risk assessment
Cell activation
Computational fluid dynamic
Endothelial cell activation potential
Oscillatory shear index
Relative residence time
Residence time
Risks assessments
Rupture risk
Time average wall shear stress
Time averages
Wall shear stress
Wall-shear stress
Endothelial cells
abdominal aortic aneurysm
aneurysm rupture
blood flow
computational fluid dynamics
endothelial cell activation potential
flow rate
hemodynamic parameters
oscillatory shear index
relative residence time
shear stress
time averaged wall shear stress
biological model
endothelium cell
mechanical stress
risk assessment
Aortic Aneurysm, Abdominal
Endothelial Cells
Models, Cardiovascular
Risk Assessment
Stress, Mechanical
Issue Date: 2023
Publisher: Elsevier Ltd
Abstract: An abdominal aortic aneurysm (AAA) is a critical health condition with a risk of rupture, where the diameter of the aorta enlarges more than 50% of its normal diameter. The incidence rate of AAA has increased worldwide. Currently, about three out of every 100,000 people have aortic diseases. The diameter and geometry of AAAs influence the hemodynamic forces exerted on the arterial wall. Therefore, a reliable assessment of hemodynamics is crucial for predicting the rupture risk. Wall shear stress (WSS) is an important metric to define the level of the frictional force on the AAA wall. Excessive levels of WSS deteriorate the remodeling mechanism of the arteries and lead to abnormal conditions. At this point, WSS-related hemodynamic parameters, such as time-averaged WSS (TAWSS), oscillatory shear index (OSI), endothelial cell activation potential (ECAP), and relative residence time (RRT) provide important information to evaluate the shear environment on the AAA wall in detail. Calculation of these parameters is not straightforward and requires a physical understanding of what they represent. In addition, computational fluid dynamics (CFD) solvers do not readily calculate these parameters when hemodynamics is simulated. This review aims to explain the WSS-derived parameters focusing on how these represent different characteristics of disturbed hemodynamics. A representative case is presented for spatial and temporal formulation that would be useful for interested researchers for practical calculations. Finally, recent hemodynamics investigations relating WSS-related parameters with AAA rupture risk assessment are presented. This review will be useful to understand the physical representation of WSS-related parameters in cardiovascular flows and how they can be calculated practically for AAA investigations. © 2023
ISSN: 0010-4825
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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