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Title: In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats
Authors: Demirkaya, Kadriye
Can, Demirdöğen Birsen
Torun, Zeynep Öncel
Erdem, Onur
Çetinkaya, Serdar
Akay, Cemal
Keywords: theracal lc
mta fillapex
mta angelus
mineral trioxide aggregate
Issue Date: Feb-2016
Publisher: Wiley
Source: Demirkaya, K., Can Demirdöğen, B., Öncel Torun, Z., Erdem, O., Çetinkaya, S., & Akay, C. (2016). In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats. European journal of oral sciences, 124(1), 75-81.
Abstract: Our aim was to test whether the presence of three hydraulic calcium silicate dental cements - MTA Angelus, MTA Fillapex, and Theracal LC - in the dental extraction socket of an in vivo model, would affect the levels of aluminium (Al) in the plasma and liver. Following anesthesia, the right upper incisor of each male Wistar albino rat was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex, or Theracal LC were inserted into the depth of the extraction socket and gingival tissue was sutured. The rats were killed 7, 30, or 60 d after the operation. Blood and liver samples were obtained from the rats before they were killed, and the levels of Al were measured by atomic absorption spectrometry. Plasma Al levels were higher in the rats in which the mineral trioxide aggregate (MTA) cements were implanted, especially MTA Angelus and MTA Fillapex, compared with control rats. In liver samples, however, the differences in Al level were not statistically significant. Our results show that Al might have been released into the circulation from the three dental cements tested, especially MTA Angelus and MTA Fillapex. Further research should be carried out on the possible biological effects of Al liberated from dental cements.
ISSN: 0909-8836
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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