Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10402
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dc.contributor.authorCan Demirdöğen, Birsen-
dc.contributor.authorDemirkaya-Budak, S.-
dc.date.accessioned2023-04-16T10:02:15Z-
dc.date.available2023-04-16T10:02:15Z-
dc.date.issued2023-
dc.identifier.issn1471-2415-
dc.identifier.urihttps://doi.org/10.1186/s12886-023-02850-3-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10402-
dc.description.abstractPurpose: Pseudoexfoliation syndrome (PEX) is distinguished by the deposition of fibrillary material within the aqueous humor and, in most cases, causes pseudoexfoliative glaucoma (PEG). The pathophysiologies of PEX and PEG are not completely explained. Therefore, this study aimed to assess the potential relationship between single nucleotide polymorphisms (SNPs) in the 3ʹ untranslated region or introns of the clusterin gene (CLU) and the susceptibility to developing PEG or PEX. Methods: Two hundred and forty patients with PEX, 239 patients with PEG, and 240 control subjects were included. Genotyping was carried out using real-time PCR (rs2279590 C/T and rs1532278 C/T) or PCR followed by restriction endonuclease digestion (rs11136000 C/T and rs3087554 T/C). Results: The minor alleles or genotypes of CLU SNPs were not significantly associated with PEX or PEG. IOP values of patients with PEX carrying the homozygote polymorphic TT genotype were significantly elevated compared with PEX cases with the CT or CC genotypes for rs2279590, rs11136000 and rs1532278 (P =.009, P =.007, P =.010, respectively). Conclusion: We present the first evidence that three SNPs in CLU gene (rs2279590, rs11136000 and rs1532278) might induce a rise in IOP in patients with PEX, conferring susceptibility to develop PEG. © 2023, The Author(s).en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 115S360en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK, 115S360).en_US
dc.language.isoenen_US
dc.publisherBioMed Central Ltden_US
dc.relation.ispartofBMC Ophthalmologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectChaperoneen_US
dc.subjectPolymorphismen_US
dc.subjectSNPen_US
dc.subjectSusceptibilityen_US
dc.subjectVariationen_US
dc.titleInfluence of clusterin genetic variants on IOP elevation in pseudoexfoliation syndrome and pseudoexfoliative glaucoma in Turkish populationen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliğitr_TR
dc.identifier.volume23en_US
dc.identifier.issue1en_US
dc.identifier.wosWOS:000957006800002en_US
dc.identifier.scopus2-s2.0-85150963242en_US
dc.institutionauthorDemirdöğen, Birsen Can-
dc.institutionauthorDemirkaya-Budak, Sinemtr_TR
dc.identifier.doi10.1186/s12886-023-02850-3-
dc.authorscopusid58159606600-
dc.authorscopusid57210150454-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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