Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10779
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dc.contributor.authorLuo, L.-
dc.contributor.authorManda, S.-
dc.contributor.authorPark, Y.-
dc.contributor.authorDemir, B.-
dc.contributor.authorSanchez, J.-
dc.contributor.authorAnantram, M.P.-
dc.contributor.authorOren, E.E.-
dc.date.accessioned2023-10-24T07:03:36Z-
dc.date.available2023-10-24T07:03:36Z-
dc.date.issued2023-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://doi.org/10.1038/s41467-023-40870-1-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/10779-
dc.description.abstractBiological membrane channels mediate information exchange between cells and facilitate molecular recognition. While tuning the shape and function of membrane channels for precision molecular sensing via de-novo routes is complex, an even more significant challenge is interfacing membrane channels with electronic devices for signal readout, which results in low efficiency of information transfer - one of the major barriers to the continued development of high-performance bioelectronic devices. To this end, we integrate membrane spanning DNA nanopores with bioprotonic contacts to create programmable, modular, and efficient artificial ion-channel interfaces. Here we show that cholesterol modified DNA nanopores spontaneously and with remarkable affinity span the lipid bilayer formed over the planar bio-protonic electrode surface and mediate proton transport across the bilayer. Using the ability to easily modify DNA nanostructures, we illustrate that this bioprotonic device can be programmed for electronic recognition of biomolecular signals such as presence of Streptavidin and the cardiac biomarker B-type natriuretic peptide, without modifying the biomolecules. We anticipate this robust interface will allow facile electronic measurement and quantification of biomolecules in a multiplexed manner. © 2023, Springer Nature Limited.en_US
dc.description.sponsorshipNational Science Foundation, NSF: 20-518; University of California, UC: 22-601; University of Washington, UW; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 2214-Aen_US
dc.description.sponsorshipL.L., S.M., Y.P., B.D., J.S., M.P.A., E.E.O., A.G. and M.R. acknowledge the main financial support of the National Science Foundation (NSF 20-518). L.L. thanks to Dr. Tom Yuzvinsky in BSOE at University of California, Santa Cruz for his help about the fabrication of bioprotonic devices. B.D. acknowledges the support of the Hyak supercomputer system at the University of Washington and financial support from the TUBITAK International Doctoral Research Fellowship program (TUBITAK 2214-A). J.S. acknowledges the support of the University of California, Santa Cruz Research Experiences for Undergraduates (REU) in sustainable materials, which is supported by the National Science Foundation (NSF 22-601).en_US
dc.language.isoenen_US
dc.publisherNature Researchen_US
dc.relation.ispartofNature Communicationsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbrain natriuretic peptideen_US
dc.subjectDNAen_US
dc.subjectDNAen_US
dc.subjectbiomarkeren_US
dc.subjectDNAen_US
dc.subjectelectrodeen_US
dc.subjectelectronic equipmenten_US
dc.subjectlipiden_US
dc.subjectmembraneen_US
dc.subjectmolecular analysisen_US
dc.subjectpeptideen_US
dc.subjectsignalen_US
dc.subjectArticleen_US
dc.subjectartificial membraneen_US
dc.subjectDNA structureen_US
dc.subjectgenetic markeren_US
dc.subjectlipid bilayeren_US
dc.subjectmembrane channelen_US
dc.subjectmolecular recognitionen_US
dc.subjectproton transporten_US
dc.subjectsurface propertyen_US
dc.subjectartificial membraneen_US
dc.subjectcell membraneen_US
dc.subjectCell Membraneen_US
dc.subjectDNAen_US
dc.subjectLipid Bilayersen_US
dc.subjectMembranes, Artificialen_US
dc.subjectNanoporesen_US
dc.titleDNA nanopores as artificial membrane channels for bioprotonicsen_US
dc.typeArticleen_US
dc.departmentTOBB ETÜen_US
dc.identifier.volume14en_US
dc.identifier.issue1en_US
dc.identifier.wosWOS:001072382600015en_US
dc.identifier.scopus2-s2.0-85169695721en_US
dc.institutionauthor-
dc.identifier.pmid37666808en_US
dc.identifier.doi10.1038/s41467-023-40870-1-
dc.authorscopusid57283676900-
dc.authorscopusid58251798400-
dc.authorscopusid57201267069-
dc.authorscopusid57204554850-
dc.authorscopusid58561630000-
dc.authorscopusid57203174991-
dc.authorscopusid35846321000-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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