Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/10858
Title: Wnt signaling in periodontitis
Authors: Güney, Zeliha
Kurgan, Sivge
Önder, Canan
Tayman, Mahmure Ayse
Günhan, Oemer
Kantarcı, Alpdoğan
Serdar, Muhittin Abdülkadir
Keywords: Periodontitis
Wnt 3a
Wnt 5a
Wnt 10b
beta-Catenin
Gene-Expression
Wnt/Beta-Catenin
Wingless Homolog
Beta-Catenin
Bone
Protein
Cells
Transcription
Promotes
Differentiation
Issue Date: 2023
Publisher: Springer Heidelberg
Abstract: ObjectiveThis study aimed to evaluate the Wnt/beta-catenin signaling pathway activity in gingival samples obtained from patients with periodontitis.Materials and methodsFifteen patients with stage III grade B (SIIIGB) and eleven with stage III grade C (SIIIGC) periodontitis were included and compared to 15 control subjects. beta-Catenin, Wnt 3a, Wnt 5a, and Wnt 10b expressions were evaluated by Q-PCR. Topographic localization of tissue beta-catenin, Wnt 5a, and Wnt 10b was measured by immunohistochemical analysis. TNF-alpha was used to assess the inflammatory state of the tissues, while Runx2 was used as a mediator of active destruction.ResultsWnt 3a, Wnt 5a, and Wnt 10b were significantly higher in gingival tissues in both grades of stage 3 periodontitis compared to the control group (p < 0.05). beta-Catenin showed intranuclear staining in connective tissue in periodontitis, while it was confined to intracytoplasmic staining in epithelial tissue and the cell walls in the control group. Wnt5a protein expression was elevated in periodontitis, with the most intense staining observed in the connective tissue of SIIIGC samples. Wnt10b showed the highest density in the connective tissue of patients with periodontitis.ConclusionsOur findings suggested that periodontal inflammation disrupts the Wnt/beta-catenin signaling pathway.Clinical RelevancePeriodontitis disrupts Wnt signaling in periodontal tissues in parallel with tissue inflammation and changes in morphology. This change in Wnt-related signaling pathways that regulate tissue homeostasis in the immunoinflammatory response may shed light on host-induced tissue destruction in the pathogenesis of the periodontal disease.
URI: https://doi.org/10.1007/s00784-023-05294-7
https://hdl.handle.net/20.500.11851/10858
ISSN: 1432-6981
1436-3771
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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