Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/11042
Title: The cerium oxide nanoparticles toxicity induced physiological, histological and biochemical alterations in freshwater mussels, Unio crassus
Authors: Türkmen, E.U.
Arslan, P.
Erkoç, F.
Günal, A.Ç.
Duran, H.
Keywords: Freshwater mussels
Histopathology
Metal oxide nanoparticle
Nano-CeO2
Oxidative stress biomarkers
cerium oxide
glutathione
glutathione transferase
nanoparticle
animal cell
animal experiment
animal tissue
Article
biochemistry
chemical analysis
chemical structure
concentration (parameter)
controlled study
ecosystem
food web
gill
gland tissue
hemolymph
histology
histopathology
mussel
nonhuman
oxidative stress
physiological process
tissue injury
Unio crassus
Issue Date: 2024
Publisher: Elsevier GmbH
Abstract: Introduction: Releasing of cerium oxide nanoparticles (nano-CeO2) to the nature has increased due to the widespread use in many fields ranging from cosmetics to the food industry. Therefore, nano-CeO2 has been included in the Organization for Economic Co-operation and Development's (OECD) priority list for engineering nanomaterials. In this study, the effects of nano-CeO2 on the freshwater mussels were investigated to reveal the impact on the freshwater systems on model organism. Methods: First, the chemical and structural properties of nano-CeO2 were characterized in details. Second, the freshwater mussels were exposed to environmentally relevant concentrations of nano-CeO2 as 10 mg, 25 mg and 50 mg/L during 48-h and 7-d. Third, after the exposure periods, hemolymph and tissue samples were taken to analyse the Total Hemocyte Counts (THCs) histology and oxidative stress parameters (total antioxidant status, glutathione, glutathione-S-transferase, and advanced oxidative protein products). Results: Significant decrease of the THCs was observed in the nano-CeO2 exposed mussels compared to the control group (P < 0.05). The histological results showed a positive association between nano-CeO2 exposure concentration in the water and level of tissue damage and histopathological alterations were detected in the gill and the digestive gland tissues. Oxidative stress parameters were slightly affected after exposure to nano-CeO2 (P > 0.05). In conclusion, this study showed that acute exposure of freshwater mussels to nano-CeO2 did not pose significant biological risk. However, it has been proven that mussels are able to accumulate nano-CeO2 significantly in their bodies. Conclusion: This suggests that nano-CeO2 may be a potential risk to other organisms in the ecosystem through trophic transfer in the food-web based on their habitat and niche in the ecosystem. © 2024 Elsevier GmbH
URI: https://doi.org/10.1016/j.jtemb.2023.127371
https://hdl.handle.net/20.500.11851/11042
ISSN: 0946-672X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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