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Title: Spatially Explicit Models to Investigate Geographic Patterns in the Distribution of Forensic STRs: Application to the North-Eastern Mediterranean.
Authors: Messina, Francesco
Finocchio, Andrea 
Akar, Nejat
Loutradis, Aphrodite
Michalodimitrakis, Emmanuel I.
Brdicka, Radim
Jodice, Carla
Novelletto, Andrea
Keywords: Cell-Line Panel
Landscape Genetics
Haplogroup-J; Europe
Issue Date: Nov-2016
Publisher: Public Library of Science
Source: Messina, F., Finocchio, A., Akar, N., Loutradis, A., Michalodimitrakis, E. I., Brdicka, R., . . . Novelletto, A. (2016). Spatially explicit models to investigate geographic patterns in the distribution of forensic STRs: Application to the north-eastern mediterranean. PLoS ONE, 11(11) doi:10.1371/journal.pone.0167065
Abstract: Human forensic STRs used for individual identification have been reported to have little power for inter-population analyses. Several methods have been developed which incorporate information on the spatial distribution of individuals to arrive at a description of the arrangement of diversity. We genotyped at 16 forensic STRs a large population sample obtained from many locations in Italy, Greece and Turkey, i.e. three countries crucial to the understanding of discontinuities at the European/Asian junction and the genetic legacy of ancient migrations, but seldom represented together in previous studies. Using spatial PCA on the full dataset, we detected patterns of population affinities in the area. Additionally, we devised objective criteria to reduce the overall complexity into reduced datasets. Independent spatially explicit methods applied to these latter datasets converged in showing that the extraction of information on long- to medium-range geographical trends and structuring from the overall diversity is possible. All analyses returned the picture of a background clinal variation, with regional discontinuities captured by each of the reduced datasets. Several aspects of our results are confirmed on external STR datasets and replicate those of genome-wide SNP typings. High levels of gene flow were inferred within the main continental areas by coalescent simulations. These results are promising from a microevolutionary perspective, in view of the fast pace at which forensic data are being accumulated for many locales. It is foreseeable that this will allow the exploitation of an invaluable genotypic resource, assembled for other (forensic) purposes, to clarify important aspects in the formation of local gene pools.
ISSN: 1932-6203
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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