Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1527
Title: Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone
Authors: Azboy, İbrahim
Özkaya, Mustafa
Demir, Teyfik
Demirtaş, Abdullah
Arslan, Arslan Kağan
Özkul, Emin
Akcan, Adnan
Tolunay, Tolga
144123
Keywords: Osteoporosis
Rat femur
Biomechanic
Genistein
Estradiol
Issue Date: 2016
Publisher: Edp Sciences S A
Source: Azboy, İ., Özkaya, M., Demir, T., Demirtaş, A., Arslan, A. K., Özkul, E., ... & Tolunay, T. (2016). Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone. SICOT-J, 2.
Abstract: Introduction: The purpose of the study is to compare the effects of genistein, estradiol, estradiol/progesterone combination on the bone mineral density and biomechanical properties of ovariectomized rats' bone. Methods: 50 female adult Sprague-Dawley rats were divided into five groups. Bilateral ovaeriectomy were performed in all groups except the sham-operated group. Groups were a sham-operated group and a control group (water was given), estradiol treated group (17-b estradiol 0.015 mg/kg per day), genistein treated group (genistein 10 mg/kg per day), and an estradiol/progesterone combination group (17-b estradiol 0.015 mg/kg plus drosperinone 0.028 mg/kg per day). The water or hormones were implemented in relevant groups for eight weeks by orogasthric catheter. The bone mineral density and biomechanical properties of the femur were analyzed. Results: Genistein, estradiol, and estradiol/progesterone groups increased bone mineral density significantly compared to the control group. In diaphysis and metaphysis bending test, all groups had higher peak load values than the control group. There were statistically significant differences between the estrogen/progesterone group and control group in diaphysis bending with regard to peak load. There were statistically significant differences between the estradiol and control groups in metaphysis bending with regard to peak load. In axial rotation test, all groups had higher peak torque values than the control groups. Conclusions: Genistein, estradiol and estrogen/progesterone combination improved the biomechanical properties of the ovariectomized rat bone. Genistein which has less side effects may be considered as an alternative in the treatment of postmenopausal osteoporosis.
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868918/
https://hdl.handle.net/20.500.11851/1527
ISSN: 2426-8887
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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