Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1780
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dc.contributor.authorZor, Murat-
dc.contributor.authorGöktaş, Serdar-
dc.contributor.authorYıldırım, İbrahim-
dc.contributor.authorZorba, Ünal Orhan-
dc.contributor.authorBaşal, Şeref-
dc.contributor.authorAlp, Bilal Fırat-
dc.contributor.authorKaya, Engin-
dc.contributor.authorEroğul, Osman-
dc.date.accessioned2019-07-08T13:29:34Z
dc.date.available2019-07-08T13:29:34Z
dc.date.issued2014-12
dc.identifier.citationZor, M., Goktas, S., Yildirim, I., Zorba, U. O., Basal, S., Alp, B. F., ... & Erogul, O. (2014). Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats. Sao Paulo Medical Journal, 132(6), 348-352.en_US
dc.identifier.issn1516-3180
dc.identifier.urihttp://dx.doi.org/10.1590/1516-3180-2014-1326625 -
dc.identifier.urihttps://hdl.handle.net/20.500.11851/1780-
dc.description.abstractCONTEXT AND OBJECTIVE: Lasers are widely used in treating symptomatic benign prostatic hyperplasia. In current practice, potassium titanyl phosphate (KTP) lasers are the most common type of laser systems used. The aim here was to evaluate the rapid effect of high-power laser systems after application of hypericin. DESIGN AND SETTING: Experimental animal study conducted in the Department of Urology, Gülhane Military Medical Academy, Ankara, Turkey, in 2012. METHODS: Sixteen rats were randomized into four groups: 120 W KTP laser + hypericin; 120 W KTP laser alone; 80 W KTP laser + hypericin; and 80 W KTP laser alone. Hypericin was given intraperitoneally two hours prior to laser applications. The laser incisions were made through the quadriceps muscle of the rats. The depth and the width of the laser incisions were evaluated histologically and recorded. RESULTS: To standardize the effects of the laser, we used the ratio of depth to width. These new values showed us the depth of the laser application per unit width. The new values acquired were evaluated statistically. Mean depth/width values were 231.6, 173.6, 214.1 and 178.9 in groups 1, 2, 3 and 4, respectively. The most notable result was that higher degrees of tissue penetration were achieved in the groups with hypericin (P < 0.05). CONCLUSIONS: The encouraging results from our preliminary study demonstrated that hypericin may improve the effects of KTP laser applications.en_US
dc.description.abstractCONTEXTO E OBJETIVO: Lasers são amplamente utilizados no tratamento de hiperplasia benigna de próstata sintomática. Na prática atual, lasers de fosfato de titanilo de potássio (KTP) são os tipos mais comuns usados dos sistemas. O objetivo foi avaliar o efeito rápido do sistema laser de alta potência após a aplicação de hipericina. TIPO DE ESTUDO E LOCAL: Estudo experimental animal, realizado no Departamento de Urologia, Academia de Medicina Militar de Gülhane, Ancara, Turquia, em 2012. MÉTODOS: 16 ratos foram divididos aleatoriamente em 4 grupos: 120W KTP laser + hipericina; 120W KTP laser somente; 80W KTP laser + hipericina; 80W KTP laser somente. Hipericina foi dada intraperitonealmente duas horas antes da aplicação do laser. As incisões a laser foram feitas através do músculo quadríceps dos ratos. A profundidade e a largura das incisões a laser foram avaliadas histologicamente e registradas. RESULTADOS: Para padronizar o efeito do laser foi utilizada a razão entre profundidade e largura. Estes novos valores nos mostraram a profundidade da aplicação do laser de largura por unidade. Os novos valores adquiridos foram avaliados estatisticamente. Os valores da média de profundidade/largura foram 231,6, 173,6, 214,1 e 178,9 nos grupos 1, 2, 3 e 4, respectivamente. O resultado mais notável foi atingir altos graus de penetração tecidual nos grupos com hipericina (P < 0,05). CONCLUSÕES: Os resultados promissores do nosso estudo preliminar mostraram que hipericina pode melhorar os efeitos das aplicações do laser KTP.en_US
dc.language.isoenen_US
dc.publisherAssocıacao Paulısta Medıcınaen_US
dc.relation.ispartofSao Paulo Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericumen_US
dc.subjectLasersen_US
dc.subjectsolid-stateen_US
dc.subjectProstatic hyperplasiaen_US
dc.subjectPhotochemotherapyen_US
dc.subjectEndoscopyen_US
dc.subject Hypericumpt_PT
dc.subjectLasers de estado sólidopt_PT
dc.subjectHiperplasia prostáticapt_PT
dc.subjectFotoquimioterapiapt_PT
dc.subjectEndoscopiapt_PT
dc.titleDoes hypericin boost the efficacy of high-power laser? A preliminary experimental study on ratsen_US
dc.title.alternativeA hipericina aumenta a eficácia do laser de alta potência? Um estudo preliminar e experimental em ratosen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume132
dc.identifier.issue6
dc.identifier.startpage348
dc.identifier.endpage352
dc.authorid0000-0002-4640-6570-
dc.identifier.wosWOS:000344469800004en_US
dc.identifier.scopus2-s2.0-84929508797en_US
dc.institutionauthorEroğul, Osman-
dc.identifier.pmid25351755en_US
dc.identifier.doi10.1590/1516-3180.2014.1326625-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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