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Title: Modification of Quartz Crystal Microbalance Surfaces via Electrospun Nanofibers Intended for Biosensor Applications
Authors: Rodoplu, Didem
Şen, Yasin
Mutlu, Mehmet
Keywords: Electrospun Nanofibers
 Plasma Surface Modification
 Quartz Crystal Microbalance
Issue Date: Apr-2013
Publisher: American Scientific Publishers
Source: Rodoplu, D., Sen, Y., & Mutlu, M. (2013). Modification of quartz crystal microbalance surfaces via electrospun nanofibers intended for biosensor applications. Nanoscience and Nanotechnology Letters, 5(4), 444-451.
Abstract: The major aim of this study is to increase the performance of mass sensitive biosensor surfaces by making modifications on quartz crystal microbalance (QCM) surfaces via electrospinning and plasma polymerization techniques. Polyvinyl alcohol (PVA) nanofibers with a diameter of approximately 150 nm were collected on the QCM surfaces by electrospinning technique. Allylamine monomer was used to create specific groups on these nanofiber coated surfaces by plasma polymerization technique. Modified surfaces were characterized by contact angle measurements, scanning electron microscopy, atomic force microscopy, fourier transform infrared spectroscopy and QCM frequency measurements in order to determine the physical and chemical characteristics of the surfaces after each experimental stage. N-H, C-N, C-H and C=O group bands were determined in the IR spectra of the materials. Decrease in the contact angle values of the modified materials indicated the increase in hydrophilicity. Those results showed that amine containing films on the surfaces were successfully deposited using plasma. The performance of modified QCM surfaces was tested via resonance frequency shifts measurements after bovine serum albumin immobilization. In this group of tests, "dip and dry" method and "flow-cell method" were performed and 548 +/- 4 Hz and 50 +/- 5 Hz frequency shifts were obtained respectively. Results of this study revealed that plasma treated electrospun PVA nanofiber modified surfaces can be used for further biosensor applications.
ISSN: 1941-4900
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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