Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1845
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dc.contributor.authorŞüküroğlu, E.-
dc.contributor.authorGüncü, G. N.-
dc.contributor.authorKılınç, Kamer-
dc.contributor.authorÇağlayan, F.-
dc.date.accessioned2019-07-10T14:39:31Z
dc.date.available2019-07-10T14:39:31Z
dc.date.issued2015-12
dc.identifier.citationSukuroglu, E., Güncü, G. N., Kilinc, K., & Caglayan, F. (2015). Using salivary nitrite and nitrate levels as a biomarker for drug-induced gingival overgrowth. Frontiers in cellular and infection microbiology, 5, 87.en_US
dc.identifier.issn2235-2988
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fcimb.2015.00087/full-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/1845-
dc.description.abstractAim: Drug-induced gingival overgrowth has a multifactorial nature and the pathogenesis is still uncertain. It has been suggested that Nitric Oxide (NO) might play a role in the pathogenesis of drug induced gingival overgrowth due to the contribution of NO to immune response and matrix degradation. NO levels in biological fluids have been used as a diagnostic biomarker in many diseases. The aim of this study is to determine whether NO levels in plasma, saliva, and gingival crevicular fluid (GCF) can serve as a potential biomarker for the evaluation of drug induced gingival overgrowth risk. Materials and Methods: A total of 104 patients, receiving cyclosporine A (p = 35), phenytoin (n = 25), nifedipine (n = 26), or diltiazem (n = 18) participated in the study. The amount of gingival overgrowth was evaluated with two indices and was given as percentage. Periodontal clinical parameters including plaque index (PI), gingival index (GI), gingival bleeding time index (GBTI), and probing depth (PD) were also assessed. Saliva, GCF, and plasma samples were obtained from each participants. Nitrite and nitrate levels in saliva, GCF, and plasma were analyzed by Griess reagent. Results: Salivary nitrite and nitrate levels in responders were significantly higher than those in non responders in only phenytoin group (p 0.05). Nitrite and nitrate levels of gingival crevicular fluid and plasma did not significantly differ between responders and non-responders in all study groups (p > 0.05). Salivary nitrite levels exhibited a significant correlation with PD, GBTI, severity of gingival overgrowth (%G0), and GCF volume (p < 0.05). Additionally, a strong positive correlation was detected between saliva and plasma nitrate levels (p < 0.005). However, both nitrite and nitrate levels in GCF and plasma demonstrated no significant correlation with clinical parameters, GO severity, and GCF volume (p > 0.05). Conclusion: Salivary nitrite and nitrate levels could be used as periodontal disease biomarkers in phenytoin induced gingival overgrowth, and that saliva seems to have a better diagnostic potential than GCF and plasma for the evaluation of drug-induced gingival overgrowth risk. However, when all drug groups were considered, saliva nitrite and nitrate levels could not be used as a biomarker for drug induced gingival overgrowth.en_US
dc.language.isoenen_US
dc.publisherFrotiers Media SA.en_US
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitric oxideen_US
dc.subjectNitriteen_US
dc.subjectNitrateen_US
dc.subjectSalivaen_US
dc.subjectDrug induced gingival overgrowthen_US
dc.subjectbiomarkeren_US
dc.titleUsing Salivary Nitrite and Nitrate Levels as a Biomarker for Drug-Induced Gingival Overgrowthen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume5
dc.identifier.startpage1
dc.identifier.endpage9
dc.identifier.wosWOS:000366270000001en_US
dc.identifier.scopus2-s2.0-85006201920en_US
dc.institutionauthorKılınç, Kamer-
dc.identifier.pmid26649282en_US
dc.identifier.doi10.3389/fcimb.2015.00087-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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