Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1860
Title: Effect of Mild Heat Stress on Heat Shock Protein 70 in a Balneotherapy Model
Authors: Uzunoğlu, E.
Yentur, S.
Kayar, A. H.
Turan, Mustafa
Dönmez, A.
Direskeneli, G. S.
Erdoğan, N.
190666
Keywords: Heat shock protein
Thermal water
Osteoarthritis
Balneotherapy
Issue Date: Jan-2017
Publisher: Elsevier Science Inc.
Source: Uzunoglu, E., Yentur, S., Kayar, A. H., Turan, M., Donmez, A., Direskeneli, G. S., & Erdogan, N. (2017). Effect of mild heat stress on heat shock protein 70 in a balneotherapy model. European Journal of Integrative Medicine, 9, 86-90. doi:10.1016/j.eujim.2016.11.014
Abstract: Introduction: Fever-induced mild heat stress plays an important role in cellular responses. The best-known heat shock response is heat shock protein (HSP) secretion. We investigated the effect of mild heat stress on serum HSP70 levels and a possible association between the immune system and these molecules by applying a mild heat stress model using a thermal water bath. Method: Peripheral blood samples from 16 osteoarthritis (OA) patients who were treated with 39-40 degrees C thermo-mineral water immersion were examined. Samples were drawn before the first bath, after the first bath, and at the end of treatment. HSP70 levels and interferon-gamma (IFN)-gamma responses in peripheral blood mononuclear cells (PBMC) were evaluated in plasma by enzyme-linked immunosorbent assay ( ELISA) and enzyme-linked immunosorbent spot (ELISPOT) assay, respectively. Results: IFN-gamma-secreting PBMC numbers were increased significantly in response to HSP70, purified protein derivative (PPD), and phytohemagglutinin (PHA) stimulation after the first bath, as compared to before bathing values (p=0.005, p=0.012, p=0.021). HSP level in serum was also increased after the first bath, and decreased to near-baseline levels after treatment, however the differences were not significant. Conclusions: The initial increase in HSP 70 and IFN-gamma levels after the first bath and the final decrease at the end of serial baths suggest that the immune system adapts to the heat stress at the end of this intervention. (C) 2016 Elsevier GmbH. All rights reserved.
URI: https://hdl.handle.net/20.500.11851/1860
ISSN: 1876-3820
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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