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Title: Predicting drug activity by image encoded gene expression profiles
Other Titles: Gen ifade profillerinin görüntü ile temsili ve ilaç aktivite tahmini
Authors: Özgül, Ozan Fırat
Bardak, Batuhan
Tan, Mehmet
Keywords: Neoplasms
Pharmaceutical Preparations
sensitivity prediction
Issue Date: 5-Jul-2018
Publisher: Institute of Electrical and Electronics Engineers Inc.
Source: Özgül, O. F., Bardak, B., and Tan, M. (2018, May). Predicting drug activity by image encoded gene expression profiles. In 2018 26th Signal Processing and Communications Applications Conference (SIU) (pp. 1-4). IEEE.
Abstract: Developing personalized cancer treatment procedures requires a prior knowledge on the effects of different drugs on cancer cell lines. While obtaining this information in vitro is a tedious task, the emergence of numerous large-scale datasets facilitates the usage of machine learning algorithms for this purpose. Conventional methods make an effort to reveal the mapping function between a cell line's identifying features called gene expressions and a certain drug's effect on it. In this work, we move away from this philosophy and represent cell lines as images in which inter-feature relations are preserved. Once these images are obtained, the regression problem is solved with the help of a convolutional neural network, a neural network architecture proven to work well with image inputs. A benchmarking with the other models in the literature exhibits the fruitfulness of our novel strategy. © 2018 IEEE.
Description: 26th IEEE Signal Processing and Communications Applications Conference (2018 : Izmir; Turkey)
Appears in Collections:Bilgisayar Mühendisliği Bölümü / Department of Computer Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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