Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/2585
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dc.contributor.authorKahraman, Ayşe-
dc.contributor.authorKonyalı, Afife-
dc.contributor.authorÇevik, Münire Özlem-
dc.date.accessioned2019-12-25T12:54:34Z-
dc.date.available2019-12-25T12:54:34Z-
dc.date.issued2019-07
dc.identifier.citationKahraman, A., Konyalı, A., & Çevik, M. Ö. (2019). Immediate and delayed effects of nutrient-sensing in fruit fly Drosophila melanogaster. Behavioural processes, 164, 133-142.en_US
dc.identifier.issn0376-6357
dc.identifier.urihttps://hdl.handle.net/20.500.11851/2585-
dc.identifier.urihttps://doi.org/10.1016/j.beproc.2019.04.016-
dc.description.abstractStarting in late 1980's, Bill Timberlake and associates conducted a series of experiments on anticipatory contrast which showed that rats’ feeding decisions were regulated by the nutritive value of currently ingested and anticipated food. The effects of nutrient sensing on feeding regulation have been studied intensively in rodents, and recently, in the fruit fly Drosophila melanogaster. In this study, we developed a new behavioral test to study rapid feeding decisions of tethered flies within 6–8 s of ingestion. Using a two-phase experimental design, we presented individual flies one of four serial combinations of a non-nutritive sugar, arabinose, or a nutritive sugar, sucrose. Feeding decisions of wildtype (Canton-S)flies are altered both by immediate effects of nutrient sensing and 1-hour delayed effects of nutrient-feeding, and the two effects act additively to yield a signature pattern of behavioral contrast based on nutritive contrast. Feeding phenotype of flies that carry a mutation of the dSLC5A11 (cupcake)gene varied with the mutant allele and genetic background. Fasted dSLC5A11 mutants showed an overeating phenotype and a defect in short-term feeding regulation irrespective of the nutritive value of sugar. Flies that carried the dSLC5A111 allele showed differential feeding for arabinose and sucrose. However, dSLC5A112 allele yielded a conspicuous deficit in delayed effects of nutrient ingestion, but only when it was expressed on a Canton-S background. Our results suggest that dSLC5A11 might function to integrate external stimulus properties and internal state for feeding regulation and action selection.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofBehavioural Processesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFeedingen_US
dc.subjectNutrient-sensingen_US
dc.subjectdSLC5A11en_US
dc.subjectcupcakeen_US
dc.subjectDrosophilamelanogasteren_US
dc.titleImmediate and delayed effects of nutrient-sensing in fruit fly Drosophila melanogasteren_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Science and Literature, Department of Psychologyen_US
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Psikoloji Bölümütr_TR
dc.identifier.volume164
dc.identifier.startpage133
dc.identifier.endpage142
dc.relation.tubitakinfo:eu-repo/grantAgreement/TÜBİTAK/SOBAG/114K826en_US
dc.identifier.wosWOS:000472692800019en_US
dc.identifier.scopus2-s2.0-85065220715en_US
dc.institutionauthorÇevik, Münire Özlem-
dc.identifier.pmid31051219en_US
dc.identifier.doi10.1016/j.beproc.2019.04.016-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept07.04. Department of Psychology-
Appears in Collections:Psikoloji Bölümü / Department of Psychology
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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