Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/2788
Title: Design and Evaluation of Phased Array Transducers for Deep Brain Stimulation in Nucleus Accumbens Region of the Rat Brain
Authors: Kılıç, Sadık Engin
Aydın, M. Akif
Ergün, Arif Şanlı
Bozkurt, Ayhan
Deveci, Erdem
Keywords: tFUS
rat skull
nucleus accumbens
Issue Date: Oct-2017
Publisher: IEEE
Source: Kilinc, M. S., Aydin, M. A., Ergun, A. S., Bozkurt, A., and Deveci, E. (2017, September). Design and evaluation of phased array transducers for deep brain stimulation in nucleus accumbens region of the rat brain. In 2017 IEEE International Ultrasonics Symposium (IUS) (pp. 1-4). IEEE.
Abstract: Transcranial focused ultrasound (tFUS) is a novel noninvasive neuromodulation method that has many potential application in the treatment of neuropsychiatric and neurologic disorders. One such application is addiction control through neuromodulation. It is hypothesized that proper stimulation of the nucleus accumbens can help in controlling or suppressing addictive behavior such as alcohol, drug and internet addiction. In this paper, we show the design and characterization of 2.5 MHz and 5 MHz transducer arrays for rat models. Designing and manufacturing an ultrasound probe for such an application presents several challenges: limited acoustic aperture in the skull, strong reflectance and attenuation of the skull, and focal size limitations due to the depth and size of the nucleus accumbens. We show with simulations and ex-vivo skull experiments that we can target nucleus accumbens in rats with reasonable accuracy and deliver enough acoustic energy across the rat skull while targeting both nucleus accumbens sites simultaneously.
URI: https://hdl.handle.net/20.500.11851/2788
https://ieeexplore.ieee.org/document/8092849
ISBN: 978-1-5386-3383-0
ISSN: 1948-5719
Appears in Collections:Elektrik ve Elektronik Mühendisliği Bölümü / Department of Electrical & Electronics Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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