Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/2884
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dc.contributor.authorAltuntaş, Sevde-
dc.contributor.authorDhaliwal, Harkiranpreet K.-
dc.contributor.authorBassous, Nicole J.-
dc.contributor.authorRadwan, Ahmed E.-
dc.contributor.authorAlpaslan, Pınar-
dc.contributor.authorWebster, Thomas-
dc.contributor.authorBüyükserin, Fatih-
dc.contributor.authorMansoor, Amiji-
dc.date.accessioned2019-12-25T14:15:47Z-
dc.date.available2019-12-25T14:15:47Z-
dc.date.issued2019-09
dc.identifier.citationAltuntas, S., Dhaliwal, H. K., Bassous, N. J., Radwan, A. E., Alpaslan, P., Webster, T., ... & Amiji, M. (2019). Nanopillared Chitosan/Gelatin Films: A Biomimetic Approach for Improved Osteogenesis. ACS Biomaterials Science & Engineering, 5(9), 4311-4322.en_US
dc.identifier.issn2373-9878
dc.identifier.urihttps://hdl.handle.net/20.500.11851/2884-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acsbiomaterials.9b00426-
dc.description.abstractBiomimicry strategies, inspired from natural organization of living organisms, are being widely used in the design of nanobiomaterials. Particularly, nonlithographic techniques have shown immense potential in the facile fabrication of nanostructured surfaces at large-scale production. Orthopedic biomaterials or coatings possessing extracellular matrix-like nanoscale features induce desirable interactions between the bone tissue and implant surface, also known as osseointegration. In this study, nanopillared chitosan/gelatin (C/G) films were fabricated using nanoporous anodic alumina molds, and their antibacterial properties as well as osteogenesis potential were analyzed by comparing to the flat C/G films and tissue culture polystyrene as controls. In vitro analysis of the expression of RUNX2, osteopontion, and osteocalcin genes for mesenchymal stem cells as well as osteoblast-like Saos-2 cells was found to be increased for the cells grown on nano C/G films, indicating early-stage osteogenic differentiation. Moreover, the mineralization tests (quantitative calcium analysis and alizarin red staining) showed that nanotopography significantly enhanced the mineralization capacity of both cell lines. This work may provide a new perspective of biomimetic surface topography fabrication for orthopedic implant coatings with superior osteogenic differentiation capacity and fast bone regeneration potential.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1059B141601323]tr_TR
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Biomaterials Science and Engineeringen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnanopillared chitosan/gelatin filmen_US
dc.subject osteogenic differentiationen_US
dc.subject mineralizationen_US
dc.titleNanopillared Chitosan/Gelatin Films: A Biomimetic Approach for Improved Osteogenesisen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume5
dc.identifier.issue9
dc.identifier.startpage4311
dc.identifier.endpage4322
dc.authorid0000-0001-6365-3808-
dc.identifier.wosWOS:000485210900014en_US
dc.identifier.scopus2-s2.0-85072580595en_US
dc.institutionauthorBüyükserin, Fatih-
dc.identifier.doi10.1021/acsbiomaterials.9b00426-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.otherTurkish Academy of Science (TUBA) Outstanding Young Scientist Award (GEBIP) Program
dc.identifier.scopusqualityQ1-
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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