Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3245
Title: Gene Expression Profiles of Tumor Necrosis Factor-alpha and Endothelin-1 in Obstructive Sleep Apnea
Authors: Uğur, Kadriye Şerife
Acar, Muradiye
Özol, Duygu
Dağlı, Elif
Öznur, Murat
Köşüş, Aydın
Gündüz, Mehmet
Keywords: Obstructive sleep apnea
Gene expression
TNF-alpha
EDN-1
Polysomnography
POLYMORPHISM; PATHOGENESIS; INFLAMMATION; ASSOCIATION
Issue Date: 2019
Publisher: KARGER
Source: Ugur, K. S., Acar, M., Ozol, D., Dagli, E., Oznur, M., Kosus, A., & Gunduz, M. (2019). Gene Expression Profiles of Tumor Necrosis Factor-? and Endothelin-1 in Obstructive Sleep Apnea. ORL, 81(1), 16-23.
Abstract: Background/Aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-alpha and endothelin (EDN)-1 and obstructive sleep apnea (OSA). Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). There were 63 patients with OSA and 45 patients without OSA. In the OSA group, the median apnea hypopnea index (AHI) was 29.1; in the non-OSA group, the median AHI was 2.1. Blood samples were obtained from all 108 patients for the genetic analysis of the expression of TNF-alpha and EDN-1. PSG findings and gene expression levels were evaluated in both groups. Results: The median (range) age was 46 (20-81) years, BMI 24.9 (15-49), EDN-1 gene expression 0.45 (0.02-67.88) pg/mu L, and TNF-alpha gene expression 1.71 (0.08-59.52) pg/mu L. We found that EDN-1 and TNF-alpha gene expression levels were significantly higher in the OSA group than in the control group (p = 0.009 vs. p < 0.001). Conclusion: EDN-1 and TNF-alpha gene expression levels were associated with the occurrence of OSA. (C) 2018 S. Karger AG, Basel
URI: https://www.karger.com/Article/Pdf/490353
https://hdl.handle.net/20.500.11851/3245
ISSN: 0301-1569
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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