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Title: Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap
Authors: Çalış, Mert
Demirtaş, Tuğrul Tolga
Sert, Gökhan
Irmak, Gülseren
Gümüşderelioğlu, Menemse
Türkkanı, Ayten
Çakar, Ayşe Nur
Özgür, Figen
Keywords: Photobiomodulation
low level laser therapy
polychromatic light
transverse rectus abdominis flap
flap delay
zone 4 necrosis
wound regeneration
Issue Date: 2019
Publisher: WILEY
Source: Calis, M., Demirtas, T. T., Sert, G., Irmak, G., Gumusderelioglu, M., Turkkani, A., ... & Ozgur, F. (2019). Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap. Lasers in surgery and medicine.
Abstract: Objective The aim of this study was to evaluate the effect of relatively novel approach of application of polychromatic light waves on flap survival of experimental musculocutaneous flap model and to investigate efficacy of this modality as a delay procedure to increase vascularization of zone 4 of transverse rectus abdominis musculocutaneous (TRAM) flap. Methods Twenty-one Wistar rats were randomized and divided into 3 experimental groups (n = 7 each). In group 1 (control group), after being raised, the TRAM flap was sutured back to its bed without any further intervention. In group 2 (delay group), photobiomodulation (PBM) was applied for 7 days as a delay procedure, before elevation of the flap. In group 3 (PBM group), the TRAM flap was elevated, and PBM was administered immediately after the flap was sutured back to its bed for therapeutic purpose. PBM was applied in 48 hours interval from 10 cm. distance to the whole abdominal wall both in groups 2 and 3 for one week. After 7 days of postoperative follow-up, as the demarcation of necrosis of the skin paddle was obvious, skin flap survival was further evaluated by macroscopic, histological and microangiographic analysis. Results The mean percentage of skin flap necrosis was 56.17 +/- 23.68 for group 1, 30.92 +/- 17.46 for group 2 and 22.73 +/- 12.98 for group 3 PBM receiving groups 2 and 3 revealed less necrosis when compared to control group and this difference was statistically significant. Vascularization in zone 4 of PBM applied groups 2 and 3 was higher compared to group 1 (P = 0.001). Acute inflammation in zone 4 of group 1 was significantly higher compared to groups 2 and 3 (P = 0.025). Similarly, evaluation of zone 1 of the flaps reveled more inflammation and less vascularization among the samples of the control group (P = 0.006 and P = 0.007, respectively). Comparison of PBM receiving two groups did not demonstrate further difference in means of vascularization and inflammation density (P = 0.259). Conclusion Application of PBM in polychromatic fashion enhances skin flap survival in experimental TRAM flap model both on preoperative basis as a delay procedure or as a therapeutic approach. Lasers Surg. 51:538-549, 2019. (c) 2019 Wiley Periodicals, Inc.
ISSN: 0196-8092
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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