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Title: The effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats
Authors: Deveci, Erdem
Kılıç, Alperen
Yılmaz, Onur
Nabi, Aynur
Ergun, Arif Şanlı
Bozkurt, Ayhan
Kurtulmus, Ayşe
Öztürk, Ahmet
Eşrefoğlu, Mukaddes
Aydın, Mehmet Şerif
Sahan, Ebru
Kırpınar, İsmet
Keywords: Morphine dependence
low intensity focused ultrasound
nucleus accumbens
conditioned place preference
deep brain stimulation
Issue Date: Oct-2019
Publisher: Taylor and Francis Ltd.
Source: Deveci, E., Kılıç, A., Yılmaz, O., Nabi, A., Ergün, A. S., Bozkurt, A., ... & Şahan, E. (2019). The effects of focused ultrasound pulsation of nucleus accumbens in opioid-dependent rats. Psychiatry and Clinical Psychopharmacology, 29(4), 748-759.
Abstract: Background: Deep Brain Stimulation (DBS) is the only modality proven to be effective on selective stimulation of the deep brain structures. It was previously reported that, by using DBS, stimulation of nucleus accumbens (NA), a region that plays a pivotal role in the pathogenesis of substance addiction, is effective for the treatment of substance addiction. Objective: The purpose of the current study was to observe how the morphine-conditioned place preference changed in rats by stimulating NA with a non-invasive method, focused ultrasound (US) and to detect whether there would be any tissue damage caused by US waves. Methods: We used low-intensity focused ultrasound (LIFU), a noninvasive modality, in a place conditioning model to stimulate NA in rats. Results: At the initial stage of our study, we used morphine to induce place preference. As expected, morphine administration caused significant place preference. After the place preference was obtained by morphine, we divided the rats into two groups. One group received LIFU waves to NA and the other group received only sham, that is, no stimulation with US waves. Rats in both groups were continued to receive morphine. Then, we investigated whether LIFU and sham will reduce morphine-induced place preference or not. We observed that morphine-induced place preference had an ongoing raise in the sham group while no raise was detected in the ultrasound group. Although LIFU prevented the rats from the raise, it did not cause a significant reduction of morphine preference. Conclusion: We state that there is a need for future studies to investigate the effects of low-intensity focused ultrasound as an alternative treatment modality in addiction.
ISSN: 24750573
Appears in Collections:Elektrik ve Elektronik Mühendisliği Bölümü / Department of Electrical & Electronics Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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