Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3371
Title: An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining
Authors: Çetin, Barbaros
Özer, Mehmet Bülent
Cagatay, Erdem
Büyükkocak, Süleyman
203366
Keywords: Acoustic fields
acoustic radiators
radiation forces
Issue Date: Jan-2016
Publisher: American Institute of Physics Inc.
Source: Cetin, B., Özer, M. B., Çağatay, E., & Büyükkocak, S. (2016). An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining. Biomicrofluidics, 10(1), 014112.
Abstract: In this study, acoustophoresis and dielectrophoresis are utilized in an integrated manner to combine the two different operations on a single polydimethylsiloxane (PDMS) chip in sequential manner, namely, particle wash (buffer exchange) and particle separation. In the washing step, particles are washed with buffer solution with low conductivity for dielectrophoretic based separation to avoid the adverse effects of Joule heating. Acoustic waves generated by piezoelectric material are utilized for washing, which creates standing waves along the whole width of the channel. Coupled electro-mechanical acoustic 3D multi-physics analysis showed that the position and orientation of the piezoelectric actuators are critical for successful operation. A unique mold is designed for the precise alignment of the piezoelectric materials and 3D side-wall electrodes for a highly reproducible fabrication. To achieve the throughput matching of acoustophoresis and dielectrophoresis in the integration, 3D side-wall electrodes are used. The integrated device is fabricated by PDMS molding. The mold of the integrated device is fabricated using high-precision mechanical machining. With a unique mold design, the placements of the two piezoelectric materials and the 3D sidewall electrodes are accomplished during the molding process. It is shown that the proposed device can handle the wash and dielectrophoretic separation successfully. (C) 2016 AIP Publishing LLC.
URI: https://hdl.handle.net/20.500.11851/3371
https://aip.scitation.org/doi/10.1063/1.4940431
ISSN: 1932-1058
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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