Melanogenesis Potential of EGF-Loaded Nano-Pillared Chitosan-Gelatin Films

Abstract

Statement of Purpose: Epidermal growth factor (EGF) has critical roles in regulation of fibroblastic activity, stimulation of keratinocytes and melanogenesis pathway. However, stability of EGF can be compromised because of physical and chemical properties of wound and this condition leads to permanent tissue defects like hypopigmentation and infection[1]. Therefore, there is a growing demand for EGF doped chitosan and gelatin scaffolds in the skin tissue engineering applications due to their biocompatible nature and optimal mechanical characteristics. The present study involves the fabrication, characterization, and potential in-vitro/in-vivo wound healing application of EGF-doped nano-pillared chitosan-gelatin films prepared using non-lithographic anodic alumina molds (AAMs) technology (Figure 1).