Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3781
Title: Chorionic villus sampling experience of a reference perinatal medicine center
Authors: Beksaç, Mehmet Sinan Sinan
Ünal, Canan
Tanacan, Atakan
Fadıloğlu, Erdem
Çakar, Ayşe Nur
Keywords: Chorionic Villus Sampling
fetal anomaly
nuchal translucency
hereditary disease
Issue Date: May-2020
Publisher: Wiley
Source: Beksaç, M. S., Unal, C., Tanacan, A., Fadiloglu, E., & Çakar, A. N. (2020). Chorionic villus sampling experience of a reference perinatal medicine center. Annals of Human Genetics, 84(3), 229-234.
Abstract: Aim: To share the chorionic villus sampling (CVS) experience of a single surgeon in our institution. Methods: This retrospective study consists of CVS cases performed between 2000 and 2018. A total of 66 types of indications were classified under two main categories, the screening group (SG) and the inherited disease group (IDG). The SG and IDG were compared in terms of clinical characteristics of the patients, Beksaç obstetrics index (BOI), timing of CVS in terms of gestational week, and complications and termination of pregnancy (TOP) rate. Results: CVS was performed at 656 women, 69 and 587 of whom were included in the SG and IDG, respectively. CVS indications of the SG were determined as advanced maternal age, high risk in combined test, fetal anomaly suspicion in ultrasonography, and increased nuchal translucency in 23, 23, 14 and 9 cases, respectively. On the other hand, CVS indications of the IDG were hereditary disorders related to hematological, muscular, and metabolic systems for 233, 179, and 116 cases, respectively. Furthermore, 32 patients had a single-gene disorder and 14 had a neurodegenerative disease. According to the results of CVS, 359 fetuses were found to be normal (54.73%), while 205 (31.25%) and 92 (14.02%) fetuses were found to be disorder-positive or carriers, respectively. Two hundred pregnant women accepted TOP. Eight (1.2%) pregnancies ended with abortion after CVS. Statistically significant differences were observed in BOI and TOP rate between SG and IDG (p: 0.042 and 0.013). Conclusion: Hereditary disorders were the most common CVS indications and the acceptance of TOP was significantly higher in this group.
URI: https://hdl.handle.net/20.500.11851/3781
https://doi.org/10.1111/ahg.12365
ISSN: 0003-4800
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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