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Title: Fetal Cell Microchimerism; Normal and Immunocompromised Gestations in Mice
Authors: Beksaç, Mehmet Sinan Sinan
Fadıloğlu, Erdem
Çakar, Ayşe Nur
Hekimoğlu, Gürbüz Rumeysa
Atilla, Pergin
Onbaşılar, İlyas
Beksaç, Kemal
Katlan, Doruk, Cevdi
Mumusoğlu, Sezcan
Çalış, Pınar
Beksaç, Meral
Keywords: Pregnancy
fetal cell microchimerism
Issue Date: 2020
Publisher: Taylor and Francis Ltd
Source: Beksac, M. S., Fadiloglu, E., Cakar, A. N., Gurbuz, R. H., Atilla, P., Onbasilar, I., ... & Beksac, M. (2019). Fetal Cell Microchimerism; Normal and Immunocompromised Gestations in Mice. Fetal and Pediatric Pathology, 1-11.
Abstract: Objective: To compare fetal cell microchimerism in normal and immunocompromised gestations. Materials and methods: The study consists of two groups of mature female mice. In the control group and the immunocompromised study group, 5 mg of saline and cyclosporine were injected intraperitoneally, respectively. In the second step, all female mice were mated with “Actine-Luc (+) green fluorescent protein (GFP)” transgenic male mice. Immunohistochemical studies (ALPL-antiluciferase, cytokeratin-antiluciferase, and CD 105-antiluciferase) were carried out on maternal liver, skin, and lung tissues at 6–7th and 14–15th gestational days, and postpartum 3–4th, 12th, and 18–24 months. Results: GFP (+) cells were detected in maternal liver and skin but not in lung tissue. Liver was the most affected tissue. GFP was found to be more intense in the immunocompromised group. Conclusion: Fetal microchimerism was demonstrated in maternal liver and skin and found to be more intensive in the immunocompromised group.
ISSN: 1551-3815
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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