Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3785
Title: Controlled drug release performance of plasma modified slab and mat matrices: A model study with “Ampicillin”
Authors: Meydan, Ahmet Ersin
Özgüzar, Hatice Ferda
Göçmen, Jülide Sedef
Mutlu, Mehmet
Keywords: Electrospinning
Spin coating
Plasma polymerization
Controlled drug release
Ampicillin
Sulfur hexafluoride
Issue Date: Sep-2020
Publisher: Elsevier B.V.
Source: Meydan, A. E., Özgüzar, H. F., Göçmen, J. S., & Mutlu, M. (2020). Controlled Drug Release Performance of Plasma Modified Slab and Mat Matrices: A Model Study with “Ampicillin”. International Journal of Pharmaceutics, 119586.
Abstract: Two types of ampicillin carrier platforms were prepared with polycaprolactone (PCL) and the release behavior of a hydrophilic model drug (ampicillin sodium salt) from those matrices was investigated. Spin coating and electrospinning techniques were used to prepare slab and mat platforms, respectively. Ampicillin sodium salt (ASS) at 5% (w:w) concentration was loaded into the slab or mat structures of PCL. The thickness of the slab was measured 3.349 ± 0.345 ?m and surface morphology of the slabs showed uniform PCL spherulites. On the other hand, fiber diameter of PCL and ASS loaded PCL (ASSLPCL) was measured 604 ± 176 nm and 549 ± 119 nm, respectively. The dynamic behavior of the controlled release was improved by a very thin film (<100 nm) formation of sulfur hexafluoride (SF6) over the surface via plasma polymerization. Plasma coating was facilitated and speed up the drug diffusion, then led to 45.60 ± 6.46% and 63.67 ± 4.33% enhancement of drug from slab and mat, respectively. Transport mechanism from all matrices showed a Fickian diffusion behavior and plasma modification of the surface did not affected the mechanism. The in vitro antibacterial property of ASS loaded matrices against S. aureus and E. coli was studied through the comparison of bacterial inhibition zones and ASS showed antibacterial effect after all processes.
URI: https://hdl.handle.net/20.500.11851/3785
https://doi.org/10.1016/j.ijpharm.2020.119586
ISSN: 0378-5173
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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