Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3914
Title: Controlled drug release behavior of metformin hydrogen chloride from biodegradable films based on chitosan/poly(ethylene glycol) methyl ether blend
Authors: Sarwar, M. Sohail
Ghaffar, Abdul
Islam, Atif
Yasmin, Farhat
Oluz, Zehra
Tuncel, Eylül
Duran, Hatice
Qaiser, Asif Ali
Keywords: Chitosan
Biodegradable films
PEGME
Controlled drug release
PBS
Biomedical applications
Issue Date: Jan-2020
Publisher: ELSEVIER
Source: Sarwar, M. S., Ghaffar, A., Islam, A., Yasmin, F., Oluz, Z., Tuncel, E., ... and Qaiser, A. A. (2020). Controlled drug release behavior of metformin hydrogen chloride from biodegradable films based on chitosan/poly (ethylene glycol) methyl ether blend. Arabian Journal of Chemistry, 13(1), 393-403.
Abstract: In this study, novel smart drug release films were prepared by blending chitosan with polyethylene glycol methyl ether (PEGME), also named as methoxy polyethylene glycol (mPEG), for controlled drug release applications. The polymeric films were characterized by Fourier transform infra-red for functional groups analysis, scanning electron microscopy for morphology and X-ray photoelectron spectroscopy for chemical and surface analysis followed by mechanical and thermal analysis. The mechanical properties showed that with the addition of PEGME (40%), the tensile strength and elongation break were increased up to 34.14 MPa and 26.40%, respectively as compared to the controlled sample (without PEGME). The developed biodegradable films were tested for Metformin hydrogen chloride release ability at a particular rate in phosphate buffer saline solution at pH 7.4. The results showed that chitosan/PEGME blends could be employed for controlled drug release and other biomedical applications. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
URI: https://hdl.handle.net/20.500.11851/3914
https://www.sciencedirect.com/science/article/pii/S187853521730093X?via%3Dihub
ISSN: 1878-5379
1878-5352
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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