Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3995
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dc.contributor.authorÖzülken, Kemal-
dc.contributor.authorÇubuk, Mehmet Özgür-
dc.contributor.authorİnan, Neşe-
dc.contributor.authorAcar, Uğur-
dc.contributor.authorGöçmen, Jülide Sedef-
dc.contributor.authorAkman, Ahmet-
dc.date.accessioned2021-01-22T06:25:58Z-
dc.date.available2021-01-22T06:25:58Z-
dc.date.issued2020
dc.identifier.citationOZULKEN, K., CUBUK, M. O., INAN, N., ACAR, U., GOCMEN, J. S., & AKMAN, A. (2020). The Comparison of Bacterial Contamination and Antibacterial Efficacy of the Anti-Glaucomatous Eyedrops.en_US
dc.identifier.issn1305-9173
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3995-
dc.identifier.urihttp://www.glaucomacataractjournal.com/abstract.php?id=871-
dc.description.abstractPurpose: To investigate the bacterial contamination risks and antimicrobial activities of the preservative-free and preservative-containing anti-glaucomatous ophthalmic solutions. Materials and Methods: Ophthalmic solution bottles of preservative-free brimonidine 0.15% (D1), benzalkonium chloride-containing (BAK) brimonidine 0.15% (D2), purite-containing brimonidine 0.15% (D3) and BAK-containing timolol maleate dorzolamide fi xed combination (D4) were included in this study in terms of microbial contamination risk. Moreover, microbial contamination of the two bottles [preservative-free brimonidine 0.15% (D7) and BAK-containing brimonidine 0.15% (D8)] was investigated after contacting their tips with the lower eyelid edge of a researcher. Every day twice a day for 60 days; the caps of the bottles were opened and they were closed after waiting for 20 sec. One drop was added from these six bottles 11 times during the study period (60 days) to the six separate and renewed blood-agar mediums. Microbial contamination was evaluated every visit by examining the blood agar mediums by the same microbiologist. In terms of antimicrobial effi cacy; D1, D2, D3 and D4 were compared with the antibiotic containing ophthalmic solutions; moxifl oxacin (D5) and tobramycin (D6) by using agar well diffusion method. Results: No bacterial growth was observed in the mediums of D1, D2, D3, D4 and D8 bottles. The bacterial growth of methicillin-susceptible and resistant coagulase-negative staphylococci was observed in the medium of D7 bottle on some days. A large inhibition zone was seen around D5 and D6, whereas a smaller inhibition zone was detected around D2 and D4. No inhibition zone was detected around the D1 and D3 bottles. Conclusions: Multi-dose preservative-free antiglaucomatous ophthalmic solutions have not any risk of bacterial contamination unless the tip of the bottle is contaminated.en_US
dc.language.isoenen_US
dc.publisherGazi Eye Foundationen_US
dc.publisherGazi Göz Vakfıtr_TR
dc.relation.ispartofThe Journal of Glaucoma&Cataracten_US
dc.relation.ispartofGlokom-Katarakt Dergisien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzalkonium chlorideen_US
dc.subjectBrimonidineen_US
dc.subjectGlaucomaen_US
dc.subjectPuriteen_US
dc.subjectMulti-dose non-preservative ophthalmic solutionsen_US
dc.titleThe Comparison of Bacterial Contamination and Antibacterial Effi cacy of the Anti-Glaucomatous Eyedrops with and without Preservativesen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Surgical Sciencesen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümütr_TR
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümütr_TR
dc.identifier.volume15
dc.identifier.issue2
dc.identifier.startpage118
dc.identifier.endpage122
dc.authorid0000-0003-2604-2981-
dc.authorid0000-0001-8207-8749-
dc.institutionauthorÖzülken, Kemal-
dc.institutionauthorGöçmen, Jülide Sedef-
dc.identifier.doi10.37844/glauc.cat.2020.15.22-
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
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