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Title: Additive Effect of Topical Nepafenac on Mydriasis in Patients With Diabetes Mellitus
Authors: Kızıltoprak, Hasan
Koç, Mustafa
Yetkin, Esat
Tekin, Kemal
İnanç, Merve
Özülken, Kemal
Keywords: Cataract surgery
Diabetes mellitus
Pupil dilation
Issue Date: Aug-2020
Publisher: Eye and Contact Lens Association (ECLA)
Source: Kiziltoprak, H., Koc, M., Yetkin, E., Tekin, K., Inanc, M., & Ozulken, K. (2020). Additive Effect of Topical Nepafenac on Mydriasis in Patients With Diabetes Mellitus. Eye & contact lens, 46(5), 310-313.
Abstract: OBJECTIVES: To evaluate the additive effect of topical nepafenac on pupil diameter (PD) in patients with diabetes mellitus (DM) and cataract. METHODS: This prospective comparative study included the patients having cataract surgery with and without DM. Two consecutive PD measurements were taken using an automatic quantitative pupillometry system (MonPack One, Metrovision). A baseline measurement was taken, then one drop of nepafenac % 0.1 (Nevanac; Alcon, Fort Worth, TX) was instilled only to the eye that will be operated on (study eye). Cyclopentolate 1.0% (Sikloplejin; Abdi İbrahim, İstanbul, Turkey) was instilled to both eyes (study eye/fellow eye) 5 minutes later. The second measurement was taken at 1 hour after this application. RESULTS: The DM group consisted of 43 patients, and the control group consisted of 39 participants. The baseline PDs of both eyes were similar in the DM group (P=0.070) and the control group (P=0.345). The change in pupil size from baseline to mydriasis was statistically significantly greater in the study eyes (2.69±0.53) than fellow eyes (2.54±0.61) in the DM group (P=0.009), but there was no statistically significant difference in the control group (2.94±0.63 vs. 2.86±0.58). When the groups were compared, the PD changes were similar in the study eyes between groups (P=0.065), while the PD changes in the fellow eyes were lower in the DM group (P=0.017). CONCLUSIONS: Nepafenac has been shown additive effect on pupil dilation in diabetic patients before cataract surgery.
ISSN: 1542-233X
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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