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Title: Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress
Authors: Kalyoncu, Şenol
Yılmaz, Bülent
Demir, Mustafa
Tuncer, Meltem
Bozdağ, Zehra
İnce, Onur
Bozdayı, Mehmet Akif
Ulusal, Hasan
Taysı, Seyithan
Keywords: ischemia-reperfusion injury
oxidative stress
rat ovarian torsion
Issue Date: Oct-2020
Publisher: Blackwell Publishing
Source: Kalyoncu, S., Yilmaz, B., Demir, M., Tuncer, M., Bozdag, Z., Ince, O., ... & Taysi, S. (2020). Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress. Journal of Obstetrics and Gynaecology Research, 46(10), 2050-2058.
Abstract: Aim: To investigate the protective effect of octreotide and lanreotide on ovarian damage in experimental ovarian ischemia–reperfusion injury. Methods: Fifty-six rats were separated into seven groups; group 1: sham group, group 2: surgical control group with 3-h torsion and detorsion, group 3: 0.02 mg/kg s.c. octreotide 30 min before 3-h torsion, group 4; octreotide just after detorsion for 7 days, group 5: octreotide 30 min before torsion and just after detorsion for 7 days, group 6: single time 20 mg/kg s.c. lanreotide before torsion, group 7: single time lanreotide just after detorsion. Results: All histopathological scores except congestion were significantly lower in group 1 than other groups. In addition, hemorrhage (group 2 vs 4: P < 0.05), degeneration (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.01 and group 2 vs 6: P < 0.05) and total damage score (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.05, group 2 vs 6: P < 0.05 and group 2 vs 7: P < 0.05) were significantly lower than other groups. Moreover, ovarian tissue total oxidant status and oxidative stress index levels were significantly decreased in groups 5 (both P < 0.05) and 7 (both P < 0.05) when compared to group 2. Furthermore, tissue levels of peroxynitrite were significantly higher in group 2 than groups 1, 3 and 5 (all P < 0.05). Conclusions: Octreotide and lanreotide have a protective role against ischemia–reperfusion damage in rat torsion detorsion model by improving histopathological and biochemical findings including tissue levels of total oxidant status, oxidative stress index and peroxynitrite.
ISSN: 1341-8076
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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