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Title: The other side of the medallion in heart failure: Reverse metabolic syndrome [Article]
Authors: Çetin, Elif Hande Özcan
Çetin, Mehmet Serkan
Özbay, Mustafa B.
Yaman, Nezaket M.
Könte, Hasan C.
Ekizler, Firdevs A.
Tak, Bahar T.
Kara, Meryem
Temizhan, Ahmet
Özcan, Fırat
Özeke, Özcan
Çay, Serkan
Topaloğlu, Serkan
Aras, Dursun
Keywords: Metabolic syndrome
Reverse metabolic syndrome
Heart failure
Issue Date: Oct-2020
Publisher: Elsevier B.V.
Source: Cetin, E. H. O., Cetin, M. S., Özbay, M. B., Yaman, N. M., Könte, H. C., Ekizler, F. A., ... & Aras, D. (2020). The other side of the medallion in heart failure: Reverse metabolic syndrome. Nutrition, Metabolism and Cardiovascular Diseases, 30(11), 2041-2050.
Abstract: Background and aims: Lower levels of cardiovascular risk factors are associated with an increase in mortality in H.F. To explain this paradox, the term reverse metabolic syndrome (RMetS) has recently been proposed. We suggest defining these patients with lower levels of three risk factors can be combined under the heading “RMetS.” We aimed to investigate the effect of MetS and RMetS on hemodynamic parameters and prognosis in patients with H.F. and reduced ejection fraction (HFrEF). Methods and results: We included 304 patients who were performed right heart catheterization and followed up for a median of 16 (0–48) months. We first grouped patients according to the presence of MetS or not, then we added the RMetS category and stratified patients into three groups as MetS, RMetS, and metabolic healthy. Compared with not MetS group, Pulmonary arterial pressures and VO2 were higher in MetS group. In the second step, LVEF, CI, VO2I, O2 delivery, and LVSWI were lowest in RMetS, pulmonary artery pressures were higher in MetS group. In multivariate Cox regression analysis, being in RMetS group was associated with 2.4 times and 1.8 times increased risk for composite end point (CEP) and all-cause mortality, respectively. In Kaplan Meier analysis, RMetS had the highest all-cause mortality and CEP. Conclusions: We determined that RMetS patients had the worst prognosis with unfavorable hemodynamic profile. Hence, a better understanding of the pathophysiology of RMetS may help refine the treatment targets of CV risk factors, may yield new interventions targeting catabolic syndrome.
ISSN: 0939-4753
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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