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Title: Dual-Ionomer-Based Device: Acetylcholine Transport and Nonenzymatic Sensing
Authors: Abdullayeva, Nazrin
Kumtepe, A.
Altaf, CT
Seçkin, H.
Demirci Sankır, Nurdan
Sankır, Mehmet
Keywords: Ionomer
acetylcholine transport
impedance spectroscopy
Issue Date: Oct-2020
Publisher: American Chemical Society
Source: Abdullayeva, N., Kumtepe, A., Altaf, C. T., Seckin, H., Sankir, N. D., and Sankir, M. (2020). Dual-Ionomer-Based Device: Acetylcholine Transport and Nonenzymatic Sensing. ACS Applied Materials and Interfaces, 12(44), 50039-50051.
Abstract: The malfunctioning in the release of acetylcholine (ACh+), leading to consequential damages in the neural system, has become an impulsion for the development of numerous progressive transport and detection gadgets. However, several challenges, such as laterality and complexity of transport devices, low precision of amperometric detection systems, and sumptuous, multistaged enzymatic quantification methods, have not yet been overcome. Herein, ionomers, because of their selective ion transporting nature, are chosen as suitable candidates for being implemented into both targeted ACh+ delivery and sensing systems. Based on these two approaches, for the very first time in the literature, the disulfonated poly(arylene ether sulfone) membrane is concurrently (i) used in the mimicry of transduction of the electrical-to-ionic signal in a neural network as “Acetylcholine Pen” (ACh+ Pen) and (ii) operated as a highly sensitive, conductivity-based ACh+ quantifier. Our dual device, being able to operate under an actual action potential of 55 mVbias, shows a strong potential of future applicability in real-time ionic delivery-and-sensing systems.
ISSN: 19448244
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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