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Title: Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress
Authors: Demir, Mustafa
Yılmaz, Bülent
Kalyoncu, Şenol
Tuncer, Meltem
Bozdağ, Zehra
İnce, Onur
Bozdayı, Mehmet Akif
Ulusal, Hasan
Taysi, Seyithan
Keywords: Ischemia reperfusion injury
Rat ovarian torsion
Oxidative stress index
Issue Date: Jan-2021
Publisher: Elsevier Ltd
Source: Demir, M., Yilmaz, B., Kalyoncu, S., Tuncer, M., Bozdag, Z., Ince, O., ... & Taysi, S. (2021). Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. Taiwanese Journal of Obstetrics and Gynecology, 60(1), 45-50.
Abstract: Objective: To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury. Materials and methods: Forty rats were divided equally into five groups; Group 1: sham, Group 2: surgical control with 3-hr torsion and detorsion, Group 3: 50 mg/kg p.o. metformin 30 min before 3-hr torsion, Group 4; metformin just after detorsion, Group 5; metformin 30 min before torsion and just after detorsion. Bilateral ovaries and blood sample were obtained seven days after detorsion for biochemical and histopathological evaluation. Results: Ovarian tissue total anti-oxidant status (TAS) levels were significantly increased in group 4 when compared to group 1, 2 and 3 (all p < 0.01). In addition, there was a significant decrease in tissue oxidative stress index (OSI) level in group 4 with respect to group 2 (p < 0.01). Moreover, serum levels of OSI were significantly higher in group 2 with respect to group 1 and 5 (both p < 0.05). Similarly, there was significant increase in serum levels of peroxynitrite in group 2 as compared to serum levels in group 3 and 5 (p < 0.01 and 0.05, respectively). Furthermore, there were significant decrease in histopathological scores metformin and sham groups when compared to rats in the control group (Group 2). Conclusion: Metformin reduces ischemia reperfusion injury in rat torsion detorsion model by improving histopathological and biochemical findings including TAS, OSI and peroxynitrite.
ISSN: 1028-4559
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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