Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6539
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dc.contributor.authorYıldırım, İsa-
dc.contributor.authorAnsari, Rashid-
dc.contributor.authorYetik, İmam Şamil-
dc.contributor.authorShahidi, Mahnaz-
dc.date.accessioned2021-09-11T15:37:15Z-
dc.date.available2021-09-11T15:37:15Z-
dc.date.issued2013en_US
dc.identifier.issn0090-6964-
dc.identifier.issn1573-9686-
dc.identifier.urihttps://doi.org/10.1007/s10439-013-0831-5-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/6539-
dc.description.abstractPhosphorescence lifetime imaging is commonly used to generate oxygen tension maps of retinal blood vessels by classical least squares (LS) estimation method. A spatial regularization method was later proposed and provided improved results. However, both methods obtain oxygen tension values from the estimates of intermediate variables, and do not yield an optimum estimate of oxygen tension values, due to their nonlinear dependence on the ratio of intermediate variables. In this paper, we provide an improved solution by devising a regularized direct least squares (RDLS) method that exploits available knowledge in studies that provide models of oxygen tension in retinal arteries and veins, unlike the earlier regularized LS approach where knowledge about intermediate variables is limited. The performance of the proposed RDLS method is evaluated by investigating and comparing the bias, variance, oxygen tension maps, 1-D profiles of arterial oxygen tension, and mean absolute error with those of earlier methods, and its superior performance both quantitatively and qualitatively is demonstrated.en_US
dc.description.sponsorshipNATIONAL EYE INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [R01EY017918, P30EY001792] Funding Source: NIH RePORTER; NEI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [R01 EY017918, P30 EY001792] Funding Source: Medlineen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Biomedical Engineeringen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhosphorescence lifetime imagingen_US
dc.subjectRetinal vasculaturesen_US
dc.subjectOxygen tension estimationen_US
dc.subjectSpatial regularizationen_US
dc.titleDirect Regularized Estimation of Retinal Vascular Oxygen Tension Based on an Experimental Modelen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Electrical and Electronics Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümütr_TR
dc.identifier.volume41en_US
dc.identifier.issue11en_US
dc.identifier.startpage2285en_US
dc.identifier.endpage2295en_US
dc.identifier.wosWOS:000325772900004en_US
dc.identifier.scopus2-s2.0-84896709909en_US
dc.institutionauthorYetik, Imam Şamil-
dc.identifier.pmid23732915en_US
dc.identifier.doi10.1007/s10439-013-0831-5-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept02.5. Department of Electrical and Electronics Engineering-
Appears in Collections:Elektrik ve Elektronik Mühendisliği Bölümü / Department of Electrical & Electronics Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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