Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/664
Full metadata record
DC FieldValueLanguage
dc.contributor.authorÇelebi, Aksüyek Savaş-
dc.contributor.authorBerkalp, Berkten-
dc.contributor.authorAmasyalı, Basri-
dc.date.accessioned2019-03-06T13:36:36Z
dc.date.available2019-03-06T13:36:36Z
dc.date.issued2020-10-01
dc.identifier.citationCelebi, S., Berkalp, B., & Amasyali, B. (2020). The association between thrombotic and inflammatory biomarkers and lower‐extremity peripheral artery disease. International Wound Journal.
dc.identifier.issn17424801
dc.identifier.urihttps://hdl.handle.net/20.500.11851/664-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/iwj.13407-
dc.description.abstractLower-extremity peripheral artery disease (LEAD) is associated with increased rates of mortality and morbidity. The aim of this study was to evaluate the associations among inflammatory and thrombotic markers and lower-extremity peripheral disease. A total of 280 patients were enrolled in this study. Of these patients, 152 patients had LEAD on peripheral angiography that was performed because of suspected lower-extremity peripheral disease based on history, physical examination, and non-invasive tests. The control group consisted of 128 patients without LEAD on peripheral angiography. Patients with LEAD were classified according to trans-atlantic inter-society consensus (TASC) II classification. Subsequently, patients in TASC A to B were defined as having mild to moderate peripheral artery disease, and those in TASC C to D were defined as having advanced peripheral artery disease. Thrombotic and inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the high-sensitivity C (hs-C) reactive protein level, the monocyte-to-high-density lipoprotein-cholesterol ratio, the fibrinogen to albumin ratio (FAR), and whole-blood viscosity at high shear rate (HSR) and low shear rate (LSR), were evaluated in this population. The NLR, the monocyte-to-high-density lipoprotein-cholesterol ratio, the FAR, and whole-blood viscosity, both at a LSR and a HSR, were significantly higher in patients with lower-extremity peripheral disease compared with patients without lower-extremity peripheral disease. We determined that lower-extremity peripheral disease severity was correlated with the NLR, monocyte-to-high-density lipoprotein-cholesterol ratio, FAR, whole-blood viscosity at LSR, and whole-blood viscosity at HSR (r = 0.719, P =.004; r = 0.25, P =.008; r = 0.691, P =.002; r = 0.546, P <.001; and r = 0.448, P =.001, respectively). However hs-C reactive protein levels were similar between patients with or without LEAD (2.47 ± 1.32 1.61 ± 0.91 P =.685). In addition, there was no correlation between the severity of LEAD and hs-C reactive levels. In this study, we determined that the levels of inflammatory and thrombotic biomarkers are elevated in peripheral artery disease, and these levels predict disease severity. © 2020 Medicalhelplines.com Inc and John Wiley & Sons Ltden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltd.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkersloweren_US
dc.subjectextremityperipheralen_US
dc.subjectperipheral artery disease
dc.titleThe association between thrombotic and inflammatory biomarkers and lower-extremity peripheral artery diseaseen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.identifier.volume17
dc.identifier.issue05
dc.identifier.startpage1346
dc.identifier.endpage1355
dc.authorid0000-0002-3637-0711-
dc.authorid0000-0002-4310-709X-
dc.authorid0000-0002-0009-7135-
dc.identifier.wosWOS:000534739000001en_US
dc.identifier.scopus2-s2.0-85085482765en_US
dc.institutionauthorÇelebi, Aksüyek Savaş-
dc.institutionauthorBerkalp, Berkten-
dc.institutionauthorAmasyalı, Basri-
dc.identifier.pmid32445291en_US
dc.identifier.doi10.1111/iwj.13407-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept03.14. Department of Internal Medicine-
crisitem.author.dept03.14. Department of Internal Medicine-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Mar 23, 2024

WEB OF SCIENCETM
Citations

9
checked on Mar 23, 2024

Page view(s)

170
checked on Mar 25, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.