Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/6902
Title: Inhibitory effect of novel pyrazole carboxamide derivatives on human carbonic anhydrase enzyme
Authors: Şen, Elvan
Alim, Zuhal
Duran, Hatice
İşgör, Mehmet Mustafa
Beydemir, Şükrü
Kasımoğulları, Rahmi
Ok, Salim
Keywords: Pyrazole-3-carboxamide
antiglaucoma
inhibition effect
hydrogen bonding
tautomeric structures
Issue Date: 2013
Publisher: Informa Healthcare
Abstract: The synthesis, characterization and biological evaluation of novel pyrazole carboxamide derivatives (2-9) are presented. H-1 and C-13 NMR have been used for the structure description, possible tautomeric structures determination and hydrogen bonding observation. FT-IR results have confirmed the synthesis of the pyrazole derivatives while thermal gravimetric analysis has confirmed thermal stability up to 300 degrees C. The melting temperatures are strongly dependent on their crystal structure as confirmed by differential scanning calorimetry and X-ray diffraction measurements. Impacts of 2-9 as possible antiglaucoma agents were investigated on carbonic anhydrase I and II (CA-I and II) isozymes purified from human erythrocytes in vitro. Compounds 3 and 9 had the highest inhibitory effect while compounds 6 and 8 showed the lowest inhibition.
URI: https://doi.org/10.3109/14756366.2011.651465
https://hdl.handle.net/20.500.11851/6902
ISSN: 1475-6366
Appears in Collections:Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü / Department of Material Science & Nanotechnology Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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