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Title: Long Range Correlations Between Nucleotide Triplets
Authors: Vitale, D.
Kuruoğlu, E. E.
Abul, Osman
Keywords: Bioinformatics
Long Range Correlations
Mutual Information
Issue Date: 2011
Publisher: IEEE
Source: 6th International Symposium on Health Informatics and Bioinformatics (HIBIT) -- MAY 02-05, 2011 -- Izmir Univ Econ, Izmir, TURKEY
Abstract: The study of statistical fluctuations in DNA sequences can reveal important characteristics of their organization. Particularly, in the last two decades, several studies have focused on the detection of Long Range Correlations (LRC) in DNA sequences, and on the study of particular long range dependence properties of nucleotides. Since protein coding is carried out by codons (nucleotide triplets), we conduct LRD analysis to see whether there is a long range dependence among nucleotide triplets. Our interest is not limited to auto correlations of single codons, but also extends to cross correlations over all possible pairs of nucleotide triplets. The analysis on nucleotide triplets reveal LRCs for the human Chromosomes 20 and 21. Moreover, some triplets that contain only nucleotides Adenine and Thymine are seen to exhibit correlation significantly higher than others.
ISBN: 978-1-4673-4431-9; 978-2-4673-4394-4
Appears in Collections:Bilgisayar Mühendisliği Bölümü / Department of Computer Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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