Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/716
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dc.contributor.authorLi, Yuanhui-
dc.contributor.authorArtés, Juan Manuel-
dc.contributor.authorDemir, Büşra-
dc.contributor.authorGökçe, Sümeyye-
dc.contributor.authorMohammad, Hashem M.-
dc.contributor.authorAlangari, Mashari-
dc.contributor.authorAnantram, Manjeri P.-
dc.contributor.authorÖren, Ersin Emre-
dc.contributor.authorHihath, Joshua-
dc.date.accessioned2019-03-15T10:53:06Z
dc.date.available2019-03-15T10:53:06Z
dc.date.issued2018-12-01
dc.identifier.citationLi, Y., Artés, J. M., Demir, B., Gokce, S., Mohammad, H. M., Alangari, M., ... & Hihath, J. (2018). Detection and identification of genetic material via single-molecule conductance. Nature nanotechnology, 13(12), 1167.en_US
dc.identifier.issn1748-3387
dc.identifier.urihttps://doi.org/10.1038/s41565-018-0285-x-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/716-
dc.description.abstractThe ongoing discoveries of RNA modalities (for example, non-coding, micro and enhancer) have resulted in an increased desire for detecting, sequencing and identifying RNA segments for applications in food safety, water and environmental protection, plant and animal pathology, clinical diagnosis and research, and bio-security. Here, we demonstrate that single-molecule conductance techniques can be used to extract biologically relevant information from short RNA oligonucleotides, that these measurements are sensitive to attomolar target concentrations, that they are capable of being multiplexed, and that they can detect targets of interest in the presence of other, possibly interfering, RNA sequences. We also demonstrate that the charge transport properties of RNA:DNA hybrids are sensitive to single-nucleotide polymorphisms, thus enabling differentiation between specific serotypes of Escherichia coli. Using a combination of spectroscopic and computational approaches, we determine that the conductance sensitivity primarily arises from the effects that the mutations have on the conformational structure of the molecules, rather than from the direct chemical substitutions. We believe that this approach can be further developed to make an electrically based sensor for diagnostic purposes.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Nanotechnologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDetection and identification of genetic material via single-molecule conductanceen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume13
dc.identifier.issue12
dc.identifier.startpage1167
dc.identifier.endpage1173
dc.authorid0000-0001-5902-083X-
dc.identifier.wosWOS:000452408300022en_US
dc.identifier.scopus2-s2.0-85056120966en_US
dc.institutionauthorÖren, Ersin Emre-
dc.identifier.pmid30397286en_US
dc.identifier.doi10.1038/s41565-018-0285-x-
dc.identifier.doi10.1038/s41565-018-0285-x-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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