Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7282
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dc.contributor.authorÖngürü, Önder-
dc.contributor.authorDüz, Bülent-
dc.contributor.authorŞimşek, Hakan-
dc.contributor.authorGünal, Armağan-
dc.contributor.authorGönül, Engin-
dc.date.accessioned2021-09-11T15:56:14Z-
dc.date.available2021-09-11T15:56:14Z-
dc.date.issued2015en_US
dc.identifier.issn0028-3843-
dc.identifier.urihttps://doi.org/10.1016/j.pjnns.2015.05.003-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/7282-
dc.description.abstractBackground: There are scarce data regarding the significance of the tumor size, hormonal activity and size of the pituitary tumor of the young; therefore, the study was designed to define the relation of the hormonal status of the large pituitary adenomas. Objective: We compared those features with tumors of the elderly (>40) with the young patients, and analyzed the clinicopathologic and proliferative features of pituitary macroadenomas in young adulthood (<= 40). Methods: 20-year archives of pituitary tumors in our clinics were reviewed and macroadenomas with diameter >= 3 cm were included in the study. We identified 46 pituitary adenomas and immunohistochemically stained them with pituitary hormones, p53 and Ki-67. Twenty-four cases were <= 40-year with an age range of 11-40 years (mean 28.0). Twenty-two cases were >40 with an age range of 44-78 years (mean 58.8). Results: In the young patient group, 15 (62.5%) were functional adenomas (6 prolactinomas, six growth hormone [GH], one adrenocorticotrophic hormone [ACTH] adenoma, two multi-hormonal [GH + ACTH]) and nine (37.5%) were either gonadotrophic or null cell adenomas. In the elderly group, five (22.7%) were functional adenomas (two adrenocorticotrophic hormone [ACTH] adenoma, one prolactinoma, one growth hormone [GH], one multihormonal [GH + ACTH]) and 17 (77.3%) were either gonadotrophic or null cell adenomas. Ki-67 proliferation index in adenomas of the young was approximately two-folds higher than the elderly (2.7% vs. 1.2%). Conclusion: In both groups, rare p53 positivity was identified. In conclusion, pituitary macroadenomas of the young show hormonal expression frequently with relatively high Ki-67 proliferation indices. (C)) 2015 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofNeurologia I Neurochirurgia Polskaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGianten_US
dc.subjectImmunohistochemistryen_US
dc.subjectKi-67en_US
dc.subjectMacroadenomaen_US
dc.subjectPituitary adenomaen_US
dc.titlePituitary macroadenomas (> 3 cm) in young adulthood: Pathologic and proliferative characteristicsen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Surgical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümütr_TR
dc.identifier.volume49en_US
dc.identifier.issue4en_US
dc.identifier.startpage212en_US
dc.identifier.endpage216en_US
dc.identifier.wosWOS:000358897900002en_US
dc.identifier.scopus2-s2.0-84940101529en_US
dc.institutionauthorGönül, Engin-
dc.identifier.pmid26188936en_US
dc.identifier.doi10.1016/j.pjnns.2015.05.003-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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