Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/748
Title: A comparative study of single-needle and coaxial electrospun amyloid-like protein nanofibers to investigate hydrophilic drug release behavior
Authors: Kabay, Gözde
Demirci, Ceyhun
Can, Gizem Kaleli
Meydan, Ahmet Ersin
Daşan, Beyhan Günaydın
Mutlu, Mehmet
Keywords: Coaxial electrospinning
Biphasic release
Coaxial electrospinning
Issue Date: 15-Jul-2018
Publisher: Elsevier B. V.
Source: Kabay, G., Demirci, C., Can, G. K., Meydan, A. E., Daşan, B. G., & Mutlu, M. (2018). A comparative study of single-needle and coaxial electrospun amyloid-like protein nanofibers to investigate hydrophilic drug release behavior. International journal of biological macromolecules, 114, 989-997.
Abstract: In this study, nanofibers containing an amyloid-like bovine serum albumin (AL-BSA) carrier and a model drug (ampicillin) were produced by electrospinning. The release behavior of ampicillin was compared from electrospun nanofibers prepared as either coaxial or single-needle types. SEM images showed that the membranes had a uniform and smooth structure and the core/shell fibers were found to be thicker than the core fibers. Core/shell production was proved by transmission electron microscopy images. Fourier transform infrared spectroscopy indicated the existence of compatibility between ampicillin and the AL-BSA matrix. The in vitro antimicrobial properties of ampicillin were studied through the comparison of bacterial inhibition zones and ampicillin was found to be more effective against Gram-positive Staphylococcus aureus than Gram-negative Escherichia coli. Moreover, in vitro drug release tests were conducted to explore the relationship between the shell thickness and the drug release rate. A burst release was observed for all membranes owing to the small fiber diameters and thus short diffusion lengths. For core membranes, the drug release mechanism followed Fickian transport, which was close to zero-order kinetic. A typical biphasic release mechanism was observed for the core/shell nanofibers. Overall, we present the first evidence of AL-BSA as a potential core/shell drug mediator.
URI: https://doi.org/10.1016/j.ijbiomac.2018.03.182
https://hdl.handle.net/20.500.11851/748
ISSN: 0141-8130
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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