Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/7696
Title: Thermoresponsive Oligo(ethylene glycol) Methacrylate Colloids with Antifouling Surface Properties
Authors: Yavuz, Mustafa Selman
Büyükserin, Fatih
Zengin, Zuleyha
Çamlı, Şevket Tolga
Keywords: poly(ethylene glycol) ethyl ether methacrylate
thermoresponsive
precipitation polymerization
antifouling
bovine serum albumin adsorption
Issue Date: 2011
Publisher: Wiley
Abstract: Thermoresponsive polymeric colloids attract great attention in several biotechnological applications owing to their ability to manipulate drug release characteristics in a controlled manner. Majority of these applications utilized N-isopropylacrylamide (NIPAM)-based particles for controlled drug release. Despite its advantages, such as easy chemical modification and well-documented literature, a potentially important bottleneck for NIPAM in biological applications is its tendency for nonspecific protein adsorption. Herein, we report a simple way to prepare novel thermoresponsive colloids composed of oligo(ethylene glycol) side chains via precipitation polymerization technique. In addition to displaying highly reversible thermal response, these particles also have considerably low nonspecific protein adsorption when compared with NIPAM counterparts. These crosslinked poly(ethylene glycol) ethyl ether methacrylate particles were characterized using dynamic light scattering and transmission electron microscopy. The effects of co-monomer, crosslinker and initiator on particle characteristics were investigated. Finally, particle toxicity studies were carried out using 3T3 fibroblast cell lines in MTT cytotoxicity assay. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 4800-4808, 2011
URI: https://doi.org/10.1002/pola.24927
https://hdl.handle.net/20.500.11851/7696
ISSN: 0887-624X
1099-0518
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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