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Title: Topical cyclosporine a (0.05%) treatment in dry eye patients: a comparison study of Sjogren's syndrome versus non-Sjogren's syndrome
Authors: Çubuk, Mehmet Özgür
Üçgül, Ahmet Yücel
Özgür, Armağan
Özülken, Kemal
Yüksel, Erdem
Keywords: Cyclosporine
Dry eye
Non-sjogren's syndrome
Sjogren's syndrome
Issue Date: 2021
Publisher: Springer
Abstract: Purpose To evaluate the clinical effect of topical cyclosporine A (CsA) (0.05%) on dry eye patients with Sjogren's syndrome (SS) and non-Sjogren's syndrome (NSS). Method This retrospective comparative study includes the dry eye (DE) patients who were treated with topical CsA. DE patients were divided into two groups as follows: DE with Sjogren's syndrome (DE-SS) and DE with Non-Sjogren's syndrome (DE-NSS). Dry eye parameters were recorded at baseline and each visit. Results Schirmer's test 1 scores were 2.7 +/- 0.5 mm at baseline and 3.5 +/- 0.7 mm at 12th month in DE-SS, 2.9 +/- 0.7 mm at baseline and 9.5 +/- 0.7 mm in DE-NSS groups at 12th month. Mean ST score was higher in DE-NSS group than DE-SS group at sixth and 12th months of the treatment (both p = 0.001). Tear break-up time score showed a significant improvement in DE-NSS group, and it was lower in DE-NSS group than DE-SS group group at sixth and 12th months of the treatment (p = 0.044 and 0.027, respectively). Mean OSDI score was lower in DE-NSS group than DE-SS group at sixth and 12th months of the treatment (p = 0.030 and 0.032, respectively). Conclusion Topical CsA seems to be more effective in the treatment of the DE-NSS.
ISSN: 0165-5701
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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