Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/802
Title: Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia
Authors: Akın, Dilara Fatma
Aşlar-Öner, Deniz
Kürekçi, Emin
Akar, Mehmet Nejat
Keywords: TPMT
Leukemia
Childhood
Polymorphism
Issue Date: 2018
Source: Akın, D. F., Aşlar-Öner, D., Kürekçi, E., & Akar, N. (2018). Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia. Turkish Journal of Pediatrics, 60(2).
Abstract: In this study we aim to determine the genotype distribution and allele frequencies of common TPMT (*2, *3A, *3B and *3C) polymorphisms in Turkish children with acute leukemia. The study population consisted of 169 patients aged between 1 and 15 years who were admitted to Losante Pediatric Hematology and Children`s Hospital with the diagnosis of acute leukemia. Genotyping of TPMT polymorphisms was screened with real-time PCR using fluorescence melting curve detection analysis. We found that the frequencies of four allelic variants of TPMT are *2 (238 G>C) (0,0%), *3A (460G>A and 719A>G) (1.7%), *3B (460G>A) (1,7%) and *3C (719A>G) (2.4%). Frequency of TPMT alleles increases the efficacy of leukemia treatment. Thus, TPMT genotyping can be useful for optimizing 6-MP therapy.
URI: https://hdl.handle.net/20.500.11851/802
http://www.turkishjournalpediatrics.org/abstract.php?id=1821
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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