Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8232
Title: Impact of Prematurity on the Buccal Epithelial Cells of the Neonates via Wnt/Beta-Catenin Signaling Pathway and Apoptosis
Authors: Dönmez, Hanife Güler
Çelik, Hasan Tolga
Kaykı, Gözdem
Tanacan, Atakan
Çağan, Murat
Yiğit, Şule
Yurdakok, Murat
Keywords: pregnancy
preterm birth
buccal smear
Wnt /beta-catenin signaling pathway
apoptosis
caspase-3
perinatal outcome
Tissue
Dna
Issue Date: 2021
Publisher: Thieme Medical Publ Inc
Abstract: Objective Understanding the reflections of prematurity is necessary for the management of neonatal complications. We focused on the impact of prematurity and related maternal risk factors/obstetric complications on buccal cells of the neonates via evaluation of the Wnt/beta-catenin signaling pathway and apoptosis. Study Design This study consisted of early preterm neonates (EPN) (<= 34th gestational week [gw]) (n = 36), late preterm neonates (LPN) (34th-< 37th gw) (n = 46), and term neonates (control) (>= 37th gw) (n = 56). Cohort was also subclassified according to the presence of maternal risk factors, obstetric complications, and neonatal complications. Wnt/beta-catenin signaling and caspase-3 activation pathways were studied immunocytochemically. Results Wnt/beta-catenin signaling positivity was statistically more frequent at buccal smears of the EPN and LPN groups compared with controls (p<0.001). The cutoff for gestational age at delivery in receiver operating characteristic curve with the best balance of sensitivity (67.4%) and specificity (67.3%) was 35.8th gw for determining the reduction of Wnt/beta-catenin signaling positivity (p< 0.001). The study demonstrated that obstetric complications significantly affected the activity of signaling, while maternal risk factors do not have any effect on Wnt/beta-catenin signaling pathway (p = 0.003 and p = 0.828, respectively). This study also demonstrated a significant relationship between Wnt/beta-catenin signaling pathway and the presence of neonatal complications (p = 0.015). Conclusion Dynamic characteristics of buccal cells are influenced by prematurity and related obstetric and neonatal problems. Buccal smear is a good tool to investigate the impact of prematurity and obstetric problems on perinatal outcome.
URI: https://doi.org/10.1055/s-0041-1740348
https://hdl.handle.net/20.500.11851/8232
ISSN: 0735-1631
1098-8785
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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