Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8333
Title: Computational Analysis of Wall Shear Stress Patterns on Calcified and Bicuspid Aortic Valves: Focus on Radial and Coaptation Patterns
Authors: Salman, Hüseyin Enes
Saltık, Levent
Yalçın, Hüseyin Çağatay
Keywords: computational fluid dynamics
fluid-structure interaction
wall shear stress
hemodynamics
calcification
aortic valve
Fluid-Structure Interaction
Structure Interaction-Model
Finite-Element-Analysis
Of-The-Art
Heart
Calcification
Simulations
Disease
Strain
Flow
Issue Date: 2021
Publisher: Mdpi
Abstract: Calcification and bicuspid valve formation are important aortic valve disorders that disturb the hemodynamics and the valve function. The detailed analysis of aortic valve hemodynamics would lead to a better understanding of the disease's etiology. We computationally modeled the aortic valve using simplified three-dimensional geometry and inlet velocity conditions obtained via echocardiography. We examined various calcification severities and bicuspid valve formation. Fluid-structure interaction (FSI) analyses were adapted using ANSYS Workbench to incorporate both flow dynamics and leaflet deformation accurately. Simulation results were validated by comparing leaflet movements in B-mode echo recordings. Results indicate that the biomechanical environment is significantly changed for calcified and bicuspid valves. High flow jet velocities are observed in the calcified valves which results in high transvalvular pressure difference (TPG). Wall shear stresses (WSS) increased with the calcification on both fibrosa (aorta side) and ventricularis (left ventricle side) surfaces of the leaflet. The WSS distribution is regular on the ventricularis, as the WSS values proportionally increase from the base to the tip of the leaflet. However, WSS patterns are spatially complex on the fibrosa side. Low WSS levels and spatially complex WSS patterns on the fibrosa side are considered as promoting factors for further calcification and valvular diseases.
URI: https://doi.org/10.3390/fluids6080287
https://hdl.handle.net/20.500.11851/8333
ISSN: 2311-5521
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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