Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8344
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dc.contributor.authorSezer, Eda-
dc.contributor.authorDemirdögen, Birsen Can-
dc.contributor.authorDemirkaya, Seref-
dc.contributor.authorBulut, Giray-
dc.contributor.authorAkkulak, Merve-
dc.contributor.authorEvin, Emre-
dc.contributor.authorAdali, Orhan-
dc.date.accessioned2022-01-15T13:02:35Z-
dc.date.available2022-01-15T13:02:35Z-
dc.date.issued2022-
dc.identifier.issn1590-1874-
dc.identifier.issn1590-3478-
dc.identifier.urihttps://doi.org/10.1007/s10072-021-05597-1-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8344-
dc.description.abstractBackground Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7 alpha-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain. In this study, single nucleotide polymorphisms (SNPs) within the genes CYP7A1 (rs3808607) and CYP46A1 (rs754203) were investigated for their effects on serum lipid profiles, vitamin D levels, and the risk of developing MS. Methods Patients with MS (n = 191) and controls (n = 100) were tested using the PCR-RFLP method to determine their genotypes for rs3808607 and rs754203 SNPs. Results The minor (C) allele frequency for CYP7A1 rs3808607 variation was 0.380 in patients with MS and 0.305 in control subjects (P = .074). For CYP46A1 rs754203, the frequencies of the minor (C) allele were 0.272 and 0.250 in patients and control subjects, respectively (P = .563). Serum vitamin D (25(OH)D3) concentrations were significantly lower in patients than in control subjects (P = .002). The CYP46A1 rs754203 SNP was associated with total cholesterol levels in patients, whereas the CYP7A1 rs3808607 variant was not associated with serum lipid parameters or vitamin D levels in patients or control subjects. Conclusion CYP7A1 rs3808607 and CYP46A1 rs754203 variations are not likely to confer an independent risk for MS development in the Turkish population. To the best of our knowledge, this is the first study to investigate the association between CYP46A1 rs754203 and MS risk.en_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple sclerosisen_US
dc.subjectSNPen_US
dc.subjectCholesterolen_US
dc.subjectVitamin Den_US
dc.subjectGreater-Than Cen_US
dc.subjectGenetic-Polymorphismen_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectBlood Cholesterolen_US
dc.subjectBile-Acidsen_US
dc.subjectDensityen_US
dc.subject24-Hydroxylaseen_US
dc.subject24-Hydroxycholesterolen_US
dc.subjectOxysterolsen_US
dc.subjectVariantsen_US
dc.titleAssociation of cholesterol 7 alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish populationen_US
dc.typeArticleen_US
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.authoridSezer, Eda / 0000-0002-4052-1666-
dc.identifier.wosWOS:000697619000001en_US
dc.identifier.scopus2-s2.0-85115272167en_US
dc.institutionauthorCan Demirdöğen, Birsen-
dc.identifier.pmid34546511en_US
dc.identifier.doi10.1007/s10072-021-05597-1-
dc.authorscopusid56200485400-
dc.authorscopusid56114161500-
dc.authorscopusid6602828328-
dc.authorscopusid57265152600-
dc.authorscopusid57264405800-
dc.authorscopusid57264023000-
dc.authorscopusid6603385719-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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