Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/836
Title: Engineering musculoskeletal tissue interfaces
Authors: Bayrak, Ece
Yılgör Huri, Pınar
Keywords: Tissue engineering
Functional biomaterials
Metallic surfaces
Polymeric surfaces
Scaffolds
Musculoskeletal tissue interfaces
Issue Date: 30-Apr-2018
Publisher: Frontiers Media S. A.
Source: Bayrak, E., & Yilgor Huri, P. (2018). Engineering musculoskeletal tissue interfaces. Frontiers in Materials, 5, 24.
Abstract: Tissue engineering aims to bring together biomaterials, cells, and signaling molecules within properly designed microenvironments in order to create viable treatment options for the lost or malfunctioning tissues. Design and production of scaffolds and cell-laden grafts that mimic the complex structural and functional features of tissues are among the most important elements of tissue engineering strategy. Although all tissues have their own complex structure, an even more complex case in terms of engineering a proper carrier material is encountered at the tissue interfaces, where two distinct tissues come together. The interfaces in the body can be examined in four categories; cartilage-bone and ligament-bone interfaces at the knee and the spine, tendon-bone interfaces at the shoulder and the feet, and muscle-tendon interface at the skeletal system. These interfaces are seen mainly at the soft-to-hard tissue transitions and they are especially susceptible to injury and tear due to the biomechanical inconsistency between these tissues where high strain fields are present. Therefore, engineering the musculoskeletal tissue interfaces remain a challenge. This review focuses on recent advancements in strategies for musculoskeletal interface engineering using different biomaterial-based platforms and surface modification techniques.
URI: https://doi.org/10.3389/fmats.2018.00024
https://hdl.handle.net/20.500.11851/836
ISSN: 2296-8016
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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